05 April 2011
Vol 4, Issue 167

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article demonstrating that poly(ADP-ribose) (PAR) binds to apoptosis-inducing factor (AIF) to trigger its release from mitochondria and induce parthanatos, a form of cell death distinct from apoptosis or necrosis. The images show sections of mouse brains bearing either wild-type AIF (top) or a form that does not bind PAR (bottom), following striatal injection of NMDA. [Image: Yingfei Wang, Johns Hopkins University School of Medicine]