12 April 2011
Vol 4, Issue 168
  • Contents

    • Research Articles

    • Perspective

    • Editors' Choice

      • Mitochondrial Positioning in T Cells

        Recruitment of mitochondria by a fission factor to immune synapses in T cells modulates T cell receptor signal strength.

      • One Step at a Time

        Cortical neurons rely on atypical Rho proteins Rnd2 and Rnd3 to inhibit RhoA in different compartments to allow proper migration during embryonic development.

      • Eosinophils and Metabolism

        Regulation of adipose tissue macrophages by eosinophils reveals an unexpected role for eosinophils in metabolic homeostasis.

      • Rac1 Regulates Both mTORC Complexes

        Rac1 binds to mTOR, influencing the localization and activity of both mTORC1 and mTORC2.

      • Polarized by the Light

        Light-dependent phosphorylation of the auxin efflux carrier PIN3 determines its trafficking pattern in the hypocotyl endodermis.

      • Recovering from Bladder Injury

        Hedgehog signaling activates Wnt signaling to promote regeneration of the bladder urothelium after chemical injury or injury due to infection.

About The Cover

Cover image expansion

Online Cover This week features a Research Article showing that estrogens and antiestrogens exert their opposing effects on prostate tumor growth through the transcription factors ERβ and KLF5, but through distinct mechanisms. The accompanying Perspective discusses the biological and clinical implications of this research, including the intriguing possibility that estrogens may not be necessary for transcriptional activity of ERβ and thus may not be the primary ligand for ERβ in the prostate. The image shows a section of a human prostate tumor that is positive for the presence of ERβ. [Image: Takashi Suzuki, Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan]