Contents
Vol 4, Issue 168
Contents
Research Articles
- Estrogen Regulates Tumor Growth Through a Nonclassical Pathway that Includes the Transcription Factors ERβ and KLF5
Estrogens and antiestrogens exert their opposing effects on prostate tumor growth through ERβ and KLF5, but through distinct mechanisms.
- PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes
The β isoform of phosphoinositide 3-kinase may be an effective therapeutic target in inflammatory diseases.
Perspective
- Estrogen Receptor β: Switching to a New Partner and Escaping from Estrogen
ERβ promotes apoptosis in prostate cancer cells through an estrogen-independent mechanism.
Editors' Choice
- Mitochondrial Positioning in T Cells
Recruitment of mitochondria by a fission factor to immune synapses in T cells modulates T cell receptor signal strength.
- One Step at a Time
Cortical neurons rely on atypical Rho proteins Rnd2 and Rnd3 to inhibit RhoA in different compartments to allow proper migration during embryonic development.
- Eosinophils and Metabolism
Regulation of adipose tissue macrophages by eosinophils reveals an unexpected role for eosinophils in metabolic homeostasis.
- Rac1 Regulates Both mTORC Complexes
Rac1 binds to mTOR, influencing the localization and activity of both mTORC1 and mTORC2.
- Polarized by the Light
Light-dependent phosphorylation of the auxin efflux carrier PIN3 determines its trafficking pattern in the hypocotyl endodermis.
- Recovering from Bladder Injury
Hedgehog signaling activates Wnt signaling to promote regeneration of the bladder urothelium after chemical injury or injury due to infection.
- Energy Requirements for Neuronal Polarization
A bioenergy-sensing pathway determines axon initiation and growth in neurons.