Contents

Contents

• Research Articles

  • Estrogen Regulates Tumor Growth Through a Nonclassical Pathway that Includes the Transcription Factors ERβ and KLF5

    By Yuka Nakajima, Kensuke Akaogi, Takashi Suzuki, Asami Osakabe, Chie Yamaguchi, Nanae Sunahara, Junji Ishida, Koichiro Kako, Sonoko Ogawa, Tetsuya Fujimura, Yukio Homma, Akiyoshi Fukamizu, Akiko Murayama, Keiji Kimura, Satoshi Inoue, Junn Yanagisawa

    Science Signaling12 Apr 2011 : ra22 Full AccessRestricted Access

    Estrogens and antiestrogens exert their opposing effects on prostate tumor growth through ERβ and KLF5, but through distinct mechanisms.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes

    By Suhasini Kulkarni, Cassian Sitaru, Zoltan Jakus, Karen E. Anderson, George Damoulakis, Keith Davidson, Misa Hirose, Jatinder Juss, David Oxley, Tamara A. M. Chessa, Faruk Ramadani, Herve Guillou, Anne Segonds-Pichon, Anja Fritsch, Gavin E. Jarvis, Klaus Okkenhaug, Ralf Ludwig, Detlef Zillikens, Attila Mocsai, Bart Vanhaesebroeck, Len R. Stephens, Phillip T. Hawkins

    Science Signaling12 Apr 2011 : ra23 Full AccessRestricted Access

    The β isoform of phosphoinositide 3-kinase may be an effective therapeutic target in inflammatory diseases.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspective

  • Estrogen Receptor β: Switching to a New Partner and Escaping from Estrogen

    By Yuet-Kin Leung, Shuk-Mei Ho

    Science Signaling12 Apr 2011 : pe19 Full AccessRestricted Access

    ERβ promotes apoptosis in prostate cancer cells through an estrogen-independent mechanism.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Mitochondrial Positioning in T Cells

    By John F. Foley

    Science Signaling12 Apr 2011 : ec99 Full AccessRestricted Access

    Recruitment of mitochondria by a fission factor to immune synapses in T cells modulates T cell receptor signal strength.

    • Abstract

  • One Step at a Time

    By Nancy R. Gough

    Science Signaling12 Apr 2011 : ec100 Full AccessRestricted Access

    Cortical neurons rely on atypical Rho proteins Rnd2 and Rnd3 to inhibit RhoA in different compartments to allow proper migration during embryonic development.

    • Abstract

  • Eosinophils and Metabolism

    By Kristen L. Mueller

    Science Signaling12 Apr 2011 : ec101 Full AccessRestricted Access

    Regulation of adipose tissue macrophages by eosinophils reveals an unexpected role for eosinophils in metabolic homeostasis.

    • Abstract

  • Rac1 Regulates Both mTORC Complexes

    By Elizabeth M. Adler

    Science Signaling12 Apr 2011 : ec102 Full AccessRestricted Access

    Rac1 binds to mTOR, influencing the localization and activity of both mTORC1 and mTORC2.

    • Abstract

  • Polarized by the Light

    By Wei Wong

    Science Signaling12 Apr 2011 : ec103 Full AccessRestricted Access

    Light-dependent phosphorylation of the auxin efflux carrier PIN3 determines its trafficking pattern in the hypocotyl endodermis.

    • Abstract

  • Recovering from Bladder Injury

    By Nancy R. Gough

    Science Signaling12 Apr 2011 : ec104 Full AccessRestricted Access

    Hedgehog signaling activates Wnt signaling to promote regeneration of the bladder urothelium after chemical injury or injury due to infection.

    • Abstract

  • Energy Requirements for Neuronal Polarization

    By Stella M. Hurtley

    Science Signaling12 Apr 2011 : ec105 Full AccessRestricted Access

    A bioenergy-sensing pathway determines axon initiation and growth in neurons.

    • Abstract