Thioredoxin Mediates Oxidation-Dependent Phosphorylation of CRMP2 and Growth Cone Collapse

Akifumi Morinaka; Mayumi Yamada; Rurika Itofusa; Yosuke Funato; Yuta Yoshimura; Fumio Nakamura; Takeshi Yoshimura; Kozo Kaibuchi; Yoshio Goshima; Mikio Hoshino; Hiroyuki Kamiguchi; Hiroaki Miki

doi:10.1126/scisignal.2001127

Research ArticleNeuroscience

Thioredoxin Mediates Oxidation-Dependent Phosphorylation of CRMP2 and Growth Cone Collapse

Akifumi Morinaka¹,
Mayumi Yamada²,³,
Rurika Itofusa⁴,
Yosuke Funato¹,
Yuta Yoshimura¹,
Fumio Nakamura⁵,
Takeshi Yoshimura⁶,*,
Kozo Kaibuchi⁶,
Yoshio Goshima⁵,
Mikio Hoshino²,
Hiroyuki Kamiguchi⁴, and
Hiroaki Miki¹,†

¹Laboratory of Intracellular Signaling, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
²Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan.
³Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8501, Japan.
⁴Laboratory for Neuronal Growth Mechanisms, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
⁵Department of Molecular Pharmacology and Neurobiology, Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
⁶Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, Aichi 466-8550, Japan.

↵†To whom correspondence should be addressed. E-mail: hmiki{at}protein.osaka-u.ac.jp

↵* Present address: Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.

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Science Signaling 26 Apr 2011:
Vol. 4, Issue 170, pp. ra26
DOI: 10.1126/scisignal.2001127

Akifumi Morinaka

1Laboratory of Intracellular Signaling, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

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Mayumi Yamada

2Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan.

3Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8501, Japan.

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Rurika Itofusa

4Laboratory for Neuronal Growth Mechanisms, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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Yosuke Funato

1Laboratory of Intracellular Signaling, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

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Yuta Yoshimura

1Laboratory of Intracellular Signaling, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

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Fumio Nakamura

5Department of Molecular Pharmacology and Neurobiology, Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.

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Takeshi Yoshimura

6Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, Aichi 466-8550, Japan.

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Kozo Kaibuchi

6Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, Aichi 466-8550, Japan.

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Yoshio Goshima

5Department of Molecular Pharmacology and Neurobiology, Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.

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Mikio Hoshino

2Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan.

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Hiroyuki Kamiguchi

4Laboratory for Neuronal Growth Mechanisms, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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Hiroaki Miki

1Laboratory of Intracellular Signaling, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

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For correspondence: hmiki@protein.osaka-u.ac.jp

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Thioredoxin Mediates Oxidation-Dependent Phosphorylation of CRMP2 and Growth Cone Collapse

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