Male Fertility Depends on Ca2+ Absorption by TRPV6 in Epididymal Epithelia

Petra Weissgerber; Ulrich Kriebs; Volodymyr Tsvilovskyy; Jenny Olausson; Oliver Kretz; Christof Stoerger; Rudi Vennekens; Ulrich Wissenbach; Ralf Middendorff; Veit Flockerzi; Marc Freichel

doi:10.1126/scisignal.2001791

Research ArticleReproductive Biology

Male Fertility Depends on Ca²⁺ Absorption by TRPV6 in Epididymal Epithelia

Petra Weissgerber¹,
Ulrich Kriebs¹,*,
Volodymyr Tsvilovskyy¹,*,
Jenny Olausson¹,*,
Oliver Kretz²,
Christof Stoerger¹,
Rudi Vennekens¹,
Ulrich Wissenbach¹,
Ralf Middendorff³,
Veit Flockerzi¹, and
Marc Freichel¹,†

¹Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, D-66421 Homburg, Germany.
²Institute of Anatomy and Cell Biology, Department of Neuroanatomy, University of Freiburg, 79104 Freiburg, Germany.
³Institut für Anatomie und Zellbiologie, Justus Liebig Universität Gießen, Aulweg 123, D-35385 Gießen, Germany.

↵†To whom correspondence should be addressed. E-mail: marc.freichel{at}uks.eu

↵* These authors contributed equally to this work.

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Science Signaling 03 May 2011:
Vol. 4, Issue 171, pp. ra27
DOI: 10.1126/scisignal.2001791

Petra Weissgerber

1Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, D-66421 Homburg, Germany.

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Ulrich Kriebs

1Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, D-66421 Homburg, Germany.

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Volodymyr Tsvilovskyy

1Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, D-66421 Homburg, Germany.

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Jenny Olausson

1Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, D-66421 Homburg, Germany.

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Oliver Kretz

2Institute of Anatomy and Cell Biology, Department of Neuroanatomy, University of Freiburg, 79104 Freiburg, Germany.

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Christof Stoerger

1Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, D-66421 Homburg, Germany.

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Rudi Vennekens

1Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, D-66421 Homburg, Germany.

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Ulrich Wissenbach

1Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, D-66421 Homburg, Germany.

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Ralf Middendorff

3Institut für Anatomie und Zellbiologie, Justus Liebig Universität Gießen, Aulweg 123, D-35385 Gießen, Germany.

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Veit Flockerzi

1Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, D-66421 Homburg, Germany.

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Marc Freichel

1Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, D-66421 Homburg, Germany.

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For correspondence: marc.freichel@uks.eu

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