Contents

Contents

• Research Articles

  • α-Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

    By Mark R. Silvis, Bridget T. Kreger, Wen-Hui Lien, Olga Klezovitch, G. Marianna Rudakova, Fernando D. Camargo, Dan M. Lantz, John T. Seykora, Valeri Vasioukhin

    Sci. Signal.24 May 2011 : ra33 Full AccessRestricted Access

    A cell-cell adhesion protein suppresses skin carcinoma development by attenuating the signaling of a transcriptional coactivator in the Hippo pathway.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis

    By Huei-Chi Wen, Alvaro Avivar-Valderas, Maria Soledad Sosa, Nomeda Girnius, Eduardo F. Farias, Roger J. Davis, Julio A. Aguirre-Ghiso

    Sci. Signal.24 May 2011 : ra34 Full AccessRestricted Access

    The kinase p38α may suppress breast cancer by promoting formation of the proper architecture of mammary glands.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Meeting Report

  • Progress in the Function and Regulation of ADP-Ribosylation

    By Michael O. Hottiger, Mark Boothby, Friedrich Koch-Nolte, Bernhard Lüscher, Niall M. B. Martin, Ruth Plummer, Zhao-Qi Wang, Mathias Ziegler

    Sci. Signal.24 May 2011 : mr5 Full AccessRestricted Access

    Scientists gathered in Zurich, Switzerland, to discuss new insights into cell, structural, and developmental biology of ADP-ribosylation.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 24 May 2011

    By James F. Martin, Valeri Vasioukhin, Mark R. Silvis, Annalisa M. VanHook

    Sci. Signal.24 May 2011 : pc10 Full AccessRestricted Access

    Recent research reveals details about the regulation and activity of the Hippo signaling mediator Yap.

    • Abstract
    • Full Text

• Editors' Choice

  • Anxiety Control

    By John F. Foley

    Science Signaling24 May 2011 : ec145 Full AccessRestricted Access

    Stress induces the proteolysis of the receptor tyrosine kinase EphB2 in the amygdala to promote anxiety.

    • Abstract

  • Break Down to Build Up

    By Stella M. Hurtley

    Sci. Signal.24 May 2011 : ec146 Full AccessRestricted Access

    A cellular compartment allows simultaneous protein synthesis and degradation.

    • Abstract

  • Tolerance by TLR

    By Kristen L. Mueller

    Sci. Signal.24 May 2011 : ec147 Full AccessRestricted Access

    Signaling through innate immune receptors promotes commensal bacteria colonization of the gut.

    • Abstract

  • Protect the Stem Cells

    By Wei Wong

    Sci. Signal.24 May 2011 : ec148 Full AccessRestricted Access

    CLAVATA3 peptide acts as a “vaccination” to activate pathogen defense pathways in plant shoot apical meristems.

    • Abstract

  • Unraveling p53 Dynamics

    By Elizabeth M. Adler

    Sci. Signal.24 May 2011 : ec149 Full AccessRestricted Access

    Different DNA-damaging stimuli can lead to different p53 dynamics that can be explained by features of the underlying networks.

    • Abstract

  • Prepatterned Progenitors

    By Annalisa M. VanHook

    Science Signaling24 May 2011 : ec150 Full AccessRestricted Access

    Distinct histone modifications influence the liver-versus-pancreas fate choice of endodermal cells.

    • Abstract