Contents
Vol 4, Issue 174
Contents
Research Articles
- α-Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1
A cell-cell adhesion protein suppresses skin carcinoma development by attenuating the signaling of a transcriptional coactivator in the Hippo pathway.
- p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis
The kinase p38α may suppress breast cancer by promoting formation of the proper architecture of mammary glands.
Meeting Report
- Progress in the Function and Regulation of ADP-Ribosylation
Scientists gathered in Zurich, Switzerland, to discuss new insights into cell, structural, and developmental biology of ADP-ribosylation.
Podcast
- Science Signaling Podcast: 24 May 2011
Recent research reveals details about the regulation and activity of the Hippo signaling mediator Yap.
Editors' Choice
- Anxiety Control
Stress induces the proteolysis of the receptor tyrosine kinase EphB2 in the amygdala to promote anxiety.
- Break Down to Build Up
A cellular compartment allows simultaneous protein synthesis and degradation.
- Tolerance by TLR
Signaling through innate immune receptors promotes commensal bacteria colonization of the gut.
- Protect the Stem Cells
CLAVATA3 peptide acts as a “vaccination” to activate pathogen defense pathways in plant shoot apical meristems.
- Unraveling p53 Dynamics
Different DNA-damaging stimuli can lead to different p53 dynamics that can be explained by features of the underlying networks.
- Prepatterned Progenitors
Distinct histone modifications influence the liver-versus-pancreas fate choice of endodermal cells.