Contents
Vol 4, Issue 175
Contents
Research Articles
- Reduction of Complex Signaling Networks to a Representative Kernel
An algorithmic approach enables the simplification of complex signaling networks and identifies potential therapeutic targets.
- Integration of Activating and Inhibitory Receptor Signaling by Regulated Phosphorylation of Vav1 in Immune Cells
The extent of phosphorylation of a guanine nucleotide exchange factor determines the cytotoxicity of natural killer cells.
Perspective
- Cancer Cells Exploit the Eph-Ephrin System to Promote Invasion and Metastasis: Tales of Unwitting Partners
Eph receptors and their ephrin ligands regulate contact inhibition of locomotion and its evasion in cancer cells.
Editors' Choice
- Food Fit for a Queen
A protein in royal jelly, which triggers development of a honeybee queen, is identified and activates the epidermal growth factor receptor pathway.
- Time Is Not of the Essence
Opposing signals specify cell fate along the proximal-distal axis of the chick limb.
- Sleepy Signal for Neurogenesis
The precursor of melatonin is a signaling mediator that stimulates the production of new neurons during sleep.
- Bacteria Promote Repair
Commensal bacteria in the gut stimulate repair of the epithelial barrier by stimulating reactive oxygen species production and cell migration.
- Hostile Takeover
Human cytomegalovirus uses a host-encoded antiviral protein to its own advantage.
