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Research ArticleCOMPUTATIONAL BIOLOGY
Antigen Potency and Maximal Efficacy Reveal a Mechanism of Efficient T Cell Activation
- Omer Dushek1,2,*,†,
- Milos Aleksic1,*,‡,
- Richard J. Wheeler1,
- Hao Zhang1,
- Shaun-Paul Cordoba1,
- Yan-Chun Peng3,
- Ji-Li Chen3,
- Vincenzo Cerundolo3,
- Tao Dong3,
- Daniel Coombs4, and
- Philip Anton van der Merwe1,†
- 1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
- 2Centre for Mathematical Biology, University of Oxford, Oxford OX1 3LB, UK.
- 3Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
- 4Department of Mathematics and Institute of Applied Mathematics, University of British Columbia, Vancouver, British Columbia V6T 1Z2, Canada.
- ↵†To whom correspondence should be addressed. E-mail: omer.dushek{at}path.ox.ac.uk (O.D.); anton.vandermerwe{at}path.ox.ac.uk (P.A.v.d.M.)
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Science Signaling 07 Jun 2011:
Vol. 4, Issue 176, pp. ra39
DOI: 10.1126/scisignal.2001430
Vol. 4, Issue 176, pp. ra39
DOI: 10.1126/scisignal.2001430
Omer Dushek
1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
2Centre for Mathematical Biology, University of Oxford, Oxford OX1 3LB, UK.
Milos Aleksic
1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Richard J. Wheeler
1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Hao Zhang
1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Shaun-Paul Cordoba
1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Yan-Chun Peng
3Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Ji-Li Chen
3Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Vincenzo Cerundolo
3Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Tao Dong
3Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Daniel Coombs
4Department of Mathematics and Institute of Applied Mathematics, University of British Columbia, Vancouver, British Columbia V6T 1Z2, Canada.
Philip Anton van der Merwe
1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
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