Contents
Vol 4, Issue 177
Contents
Research Articles
- Structure of a Pentavalent G-Actin•MRTF-A Complex Reveals How G-Actin Controls Nucleocytoplasmic Shuttling of a Transcriptional Coactivator
Binding of multimeric actin inhibits a transcriptional coactivator by promoting nuclear export and blocking nuclear import.
- TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer
The microRNAs miR-221 and miR-222 promote a phenotype associated with metastasis and are found in a clinically aggressive form of breast cancer.
Perspective
- IKKε: A Kinase at the Intersection of Signaling and Membrane Traffic
IKKε-mediated phosphorylation events may redirect endosomal traffic by switching the motor proteins associated with vesicles.
Podcast
- Science Signaling Podcast: 14 June 2011
Structural analysis reveals how increasing concentrations of monomeric actin prevent a transcriptional coactivator from promoting expression of target genes.
Editors' Choice
- Mechanical YAPping
The transcriptional regulators YAP and TAZ relay mechanical cues from the environment to the nucleus.
- May the Force Be with Your Tenocytes
The sudden loss of mechanical force in severed tendons leads to release of TGF-β and massive tenocyte death.
- Stressing Bacteria to Death
The bactericidal activity of mammalian peptidoglycan recognition proteins involves activation of a bacterial two-component stress defense pathway.
- mTOR Substrates Revealed
A search for substrates of a growth-promoting kinase revealed a regulatory feedback loop involved in tumor suppression.
- Smoking and Body Weight
Nicotine decreases weight gain by targeting a brain pathway involved in the regulation of energy balance and food intake.
- Seeing the Heat
Thermal activation of visual pigments involves the same chromophore-isomerization reaction as does light activation.
- Mammalian DNA Damage Response
A screen identifies proteins not previously known to function in protecting cells from DNA damage.
