TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer

Susanna Stinson; Mark R. Lackner; Alex T. Adai; Nancy Yu; Hyo-Jin Kim; Carol O’Brien; Jill Spoerke; Suchit Jhunjhunwala; Zachary Boyd; Thomas Januario; Robert J. Newman; Peng Yue; Richard Bourgon; Zora Modrusan; Howard M. Stern; Søren Warming; Frederic J. de Sauvage; Lukas Amler; Ru-Fang Yeh; David Dornan

doi:10.1126/scisignal.2001538

Research ArticleCancer Biology

TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer

Susanna Stinson¹,*,
Mark R. Lackner²,*,
Alex T. Adai³,*,
Nancy Yu¹,
Hyo-Jin Kim¹,
Carol O’Brien²,
Jill Spoerke²,
Suchit Jhunjhunwala⁴,
Zachary Boyd²,
Thomas Januario¹,
Robert J. Newman⁵,
Peng Yue⁴,
Richard Bourgon⁴,
Zora Modrusan⁵,
Howard M. Stern⁶,
Søren Warming⁵,
Frederic J. de Sauvage⁵,
Lukas Amler²,
Ru-Fang Yeh⁷, and
David Dornan¹,†

¹Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.
²Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.
³Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, CA 94143, USA.
⁴Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA.
⁵Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.
⁶Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.
⁷Department of Biostatistics, Genentech Inc., South San Francisco, CA 94080, USA.

↵†To whom correspondence should be addressed. E-mail: dornan.david{at}gene.com

↵* These authors contributed equally to this work.

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Science Signaling 14 Jun 2011:
Vol. 4, Issue 177, pp. ra41
DOI: 10.1126/scisignal.2001538

Susanna Stinson

1Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.

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Mark R. Lackner

2Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.

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Alex T. Adai

3Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, CA 94143, USA.

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Nancy Yu

1Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.

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Hyo-Jin Kim

1Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.

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Carol O’Brien

2Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.

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Jill Spoerke

2Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.

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Suchit Jhunjhunwala

4Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA.

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Zachary Boyd

2Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.

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Thomas Januario

1Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.

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Robert J. Newman

5Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.

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Peng Yue

4Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA.

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Richard Bourgon

4Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA.

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Zora Modrusan

5Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.

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Howard M. Stern

6Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.

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Søren Warming

5Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.

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Frederic J. de Sauvage

5Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.

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Lukas Amler

2Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.

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Ru-Fang Yeh

7Department of Biostatistics, Genentech Inc., South San Francisco, CA 94080, USA.

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David Dornan

1Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.

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For correspondence: dornan.david@gene.com

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TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer

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