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Research ArticleCancer Biology
TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer
- Susanna Stinson1,*,
- Mark R. Lackner2,*,
- Alex T. Adai3,*,
- Nancy Yu1,
- Hyo-Jin Kim1,
- Carol O’Brien2,
- Jill Spoerke2,
- Suchit Jhunjhunwala4,
- Zachary Boyd2,
- Thomas Januario1,
- Robert J. Newman5,
- Peng Yue4,
- Richard Bourgon4,
- Zora Modrusan5,
- Howard M. Stern6,
- Søren Warming5,
- Frederic J. de Sauvage5,
- Lukas Amler2,
- Ru-Fang Yeh7, and
- David Dornan1,†
- 1Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.
- 2Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.
- 3Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, CA 94143, USA.
- 4Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA.
- 5Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.
- 6Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.
- 7Department of Biostatistics, Genentech Inc., South San Francisco, CA 94080, USA.
- ↵†To whom correspondence should be addressed. E-mail: dornan.david{at}gene.com
-
↵* These authors contributed equally to this work.
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Science Signaling 14 Jun 2011:
Vol. 4, Issue 177, pp. ra41
DOI: 10.1126/scisignal.2001538
Vol. 4, Issue 177, pp. ra41
DOI: 10.1126/scisignal.2001538
Susanna Stinson
1Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.
Mark R. Lackner
2Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.
Alex T. Adai
3Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, CA 94143, USA.
Nancy Yu
1Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.
Hyo-Jin Kim
1Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.
Carol O’Brien
2Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.
Jill Spoerke
2Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.
Suchit Jhunjhunwala
4Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA.
Zachary Boyd
2Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.
Thomas Januario
1Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.
Robert J. Newman
5Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.
Peng Yue
4Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA.
Richard Bourgon
4Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA.
Zora Modrusan
5Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.
Howard M. Stern
6Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.
Søren Warming
5Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.
Frederic J. de Sauvage
5Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.
Lukas Amler
2Department of Development Oncology Diagnostics, Genentech Inc., South San Francisco, CA 94080, USA.
Ru-Fang Yeh
7Department of Biostatistics, Genentech Inc., South San Francisco, CA 94080, USA.
David Dornan
1Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA.
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