Contents
Vol 4, Issue 178
Contents
Research Resource
- Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control
Changes in cellular SUMOylation occur in response to the accumulation of misfolded proteins.
Journal Club
- Partners in Crime: Ubiquitin-Mediated Degradation and Autophagy
Toll-like receptor 4 signaling provides insights into the molecular mechanism of ubiquitin-dependent selective autophagy.
Presentation
- HIF-1α Mediates Tumor Hypoxia to Confer a Perpetual Mesenchymal Phenotype for Malignant Progression
Hypoxia-induced genetic alterations induce epithelial-mesenchymal transition and tumor progression.
Editors' Choice
- Acting with Actin (But Not Akt)
PTEN regulates DNA damage–induced cell size arrest through a mechanism independent of its ability to decrease Akt phosphorylation.
- Activating Sonic Hedgehog
N-terminal palmitoylation appears to position multimeric complexes of Sonic hedgehog such that protease cleavage alleviates an autoinhibitory interaction.
- Vital Signs
Detection of prokaryotic mRNA by the host distinguishes between live and dead microorganisms and enhances the immune response.
- An End to Plant Defenses
Targeted degradation of bacterial sensing proteins keeps plant defenses from running amok.
- Inhibited at the Nucleus
A nuclear pore component maintains an inactive pool of the cAMP effector Epac1 at the nuclear envelope.
- Ramping Up AMPK
The cellular energy sensor adenosine monophosphate–activated protein kinase also binds and is regulated by adenosine diphosphate.
- Coordinating Autophagy and Lysosome Regulation
Starvation activates a transcriptional program controlling autophagosome formation, lysosome fusion, and substrate degradation.
- Sirtuin 6 and DNA Repair
A genome stability regulator integrates DNA repair and stress signaling pathways.
