Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

Jes Alexander; Daniel Lim; Brian A. Joughin; Björn Hegemann; James R. A. Hutchins; Tobias Ehrenberger; Frank Ivins; Fabio Sessa; Otto Hudecz; Erich A. Nigg; Andrew M. Fry; Andrea Musacchio; P. Todd Stukenberg; Karl Mechtler; Jan-Michael Peters; Stephen J. Smerdon; Michael B. Yaffe

doi:10.1126/scisignal.2001796

Research ArticleMitotic Kinases

Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

Jes Alexander¹,*,
Daniel Lim¹,
Brian A. Joughin¹,
Björn Hegemann²,†,
James R. A. Hutchins²,
Tobias Ehrenberger¹,
Frank Ivins³,
Fabio Sessa⁴,
Otto Hudecz²,
Erich A. Nigg⁵,
Andrew M. Fry⁶,
Andrea Musacchio⁴,
P. Todd Stukenberg⁷,
Karl Mechtler²,
Jan-Michael Peters²,
Stephen J. Smerdon³, and
Michael B. Yaffe¹,⁸,‡

¹Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
²Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
³Division of Molecular Structure, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.
⁴Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20139 Milan, Italy.
⁵Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
⁶Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.
⁷Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
⁸Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

↵‡To whom correspondence should be addressed. E-mail: myaffe{at}mit.edu

↵* Present address: Department of Radiation Oncology, University of California, San Francisco, CA 94143, USA.
↵† Present address: Institute of Biochemistry, Eidgenössische Technische Hochschule Zürich, Schafmattstrasse 18, CH-8093 Zürich, Switzerland.

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Science Signaling 28 Jun 2011:
Vol. 4, Issue 179, pp. ra42
DOI: 10.1126/scisignal.2001796

Jes Alexander

1Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Daniel Lim

1Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Brian A. Joughin

1Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Björn Hegemann

2Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.

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James R. A. Hutchins

2Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.

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Tobias Ehrenberger

1Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Frank Ivins

3Division of Molecular Structure, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.

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Fabio Sessa

4Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20139 Milan, Italy.

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Otto Hudecz

2Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.

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Erich A. Nigg

5Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.

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Andrew M. Fry

6Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.

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Andrea Musacchio

4Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20139 Milan, Italy.

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P. Todd Stukenberg

7Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

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Karl Mechtler

2Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.

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Jan-Michael Peters

2Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.

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Stephen J. Smerdon

3Division of Molecular Structure, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.

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Michael B. Yaffe

1Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

8Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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For correspondence: myaffe@mit.edu

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Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

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