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Research ArticleMitotic Kinases
Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling
- Jes Alexander1,*,
- Daniel Lim1,
- Brian A. Joughin1,
- Björn Hegemann2,†,
- James R. A. Hutchins2,
- Tobias Ehrenberger1,
- Frank Ivins3,
- Fabio Sessa4,
- Otto Hudecz2,
- Erich A. Nigg5,
- Andrew M. Fry6,
- Andrea Musacchio4,
- P. Todd Stukenberg7,
- Karl Mechtler2,
- Jan-Michael Peters2,
- Stephen J. Smerdon3, and
- Michael B. Yaffe1,8,‡
- 1Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 2Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
- 3Division of Molecular Structure, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.
- 4Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20139 Milan, Italy.
- 5Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
- 6Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.
- 7Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
- 8Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- ↵‡To whom correspondence should be addressed. E-mail: myaffe{at}mit.edu
See allHide authors and affiliations
Science Signaling 28 Jun 2011:
Vol. 4, Issue 179, pp. ra42
DOI: 10.1126/scisignal.2001796
Vol. 4, Issue 179, pp. ra42
DOI: 10.1126/scisignal.2001796
Jes Alexander
1Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Daniel Lim
1Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Brian A. Joughin
1Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Björn Hegemann
2Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
James R. A. Hutchins
2Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
Tobias Ehrenberger
1Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Frank Ivins
3Division of Molecular Structure, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.
Fabio Sessa
4Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20139 Milan, Italy.
Otto Hudecz
2Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
Erich A. Nigg
5Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
Andrew M. Fry
6Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.
Andrea Musacchio
4Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20139 Milan, Italy.
P. Todd Stukenberg
7Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Karl Mechtler
2Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
Jan-Michael Peters
2Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
Stephen J. Smerdon
3Division of Molecular Structure, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.
Michael B. Yaffe
1Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
8Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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