Contents

Contents

• Research Articles

  • Sequential Phosphorylation of Smoothened Transduces Graded Hedgehog Signaling

    By Ying Su, Jason K. Ospina, Junzheng Zhang, Andrew P. Michelson, Adam M. Schoen, Alan Jian Zhu

    Science Signaling05 Jul 2011 : ra43 Full AccessRestricted Access

    It takes two kinases and two phosphatases acting on a single membrane protein Smoothened to interpret the Hedgehog morphogen gradient.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Identification of a Lysosomal Pathway That Modulates Glucocorticoid Signaling and the Inflammatory Response

    By Yuanzheng He, Yong Xu, Chenghai Zhang, Xiang Gao, Karl J. Dykema, Katie R. Martin, Jiyuan Ke, Eric A. Hudson, Sok Kean Khoo, James H. Resau, Arthur S. Alberts, Jeffrey P. MacKeigan, Kyle A. Furge, H. Eric Xu

    Science Signaling05 Jul 2011 : ra44 Full AccessRestricted Access

    Inhibition of lysosome function promotes the anti-inflammatory effects of glucocorticoid signaling.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspective

  • Bacterial Scaffolds Assemble Novel Higher-Order Complexes to Reengineer Eukaryotic Cell Processes

    By Cammie F. Lesser, John M. Leong

    Science Signaling05 Jul 2011 : pe32 Full AccessRestricted Access

    Bacterial effector proteins can act as novel scaffolds for signaling proteins in infected mammalian cells.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 5 July 2011

    By Yuanzheng He, Annalisa M. VanHook

    Science Signaling05 Jul 2011 : pc13 Full AccessRestricted Access

    The anti-inflammatory effects of chloroquine are mediated by inhibition of the lysosome, which enhances glucocorticoid signaling.

    • Abstract
    • Full Text

• Editors' Choice

  • Evading Death

    By Wei Wong

    Science Signaling05 Jul 2011 : ec184 Full AccessRestricted Access

    Sialylation of Fas may enable colon carcinoma cells to evade apoptosis.

    • Abstract

  • Dissecting Insulin's Actions in the Brain

    By Nancy R. Gough

    Science Signaling05 Jul 2011 : ec185 Full AccessRestricted Access

    Insulin-responsive neurons in the ventromedial hypothalamus contribute to obesity induced by a high-fat diet.

    • Abstract

  • Targeting Receptor Stability

    By John F. Foley

    Science Signaling05 Jul 2011 : ec186 Full AccessRestricted Access

    Targeting of caveolin-1 by microRNAs destabilizes the insulin receptor, which leads to decreased insulin sensitivity.

    • Abstract

  • Damage Limitation Exercise

    By Guy Riddihough

    Science Signaling05 Jul 2011 : ec187 Full AccessRestricted Access

    An in vitro system reveals the steps involved in repairing covalent links between DNA strands of the double helix.

    • Abstract

  • Fight, Flee, or Freeze

    By Peter R. Stern

    Science Signaling05 Jul 2011 : ec188 Full AccessRestricted Access

    Specific neuronal populations in the amygdala control different behavioral and physiological components of the fear response.

    • Abstract