Contents
Vol 4, Issue 180
Contents
Research Articles
- Sequential Phosphorylation of Smoothened Transduces Graded Hedgehog Signaling
It takes two kinases and two phosphatases acting on a single membrane protein Smoothened to interpret the Hedgehog morphogen gradient.
- Identification of a Lysosomal Pathway That Modulates Glucocorticoid Signaling and the Inflammatory Response
Inhibition of lysosome function promotes the anti-inflammatory effects of glucocorticoid signaling.
Perspective
- Bacterial Scaffolds Assemble Novel Higher-Order Complexes to Reengineer Eukaryotic Cell Processes
Bacterial effector proteins can act as novel scaffolds for signaling proteins in infected mammalian cells.
Podcast
- Science Signaling Podcast: 5 July 2011
The anti-inflammatory effects of chloroquine are mediated by inhibition of the lysosome, which enhances glucocorticoid signaling.
Editors' Choice
- Dissecting Insulin's Actions in the Brain
Insulin-responsive neurons in the ventromedial hypothalamus contribute to obesity induced by a high-fat diet.
- Targeting Receptor Stability
Targeting of caveolin-1 by microRNAs destabilizes the insulin receptor, which leads to decreased insulin sensitivity.
- Damage Limitation Exercise
An in vitro system reveals the steps involved in repairing covalent links between DNA strands of the double helix.
- Fight, Flee, or Freeze
Specific neuronal populations in the amygdala control different behavioral and physiological components of the fear response.