Contents
Vol 4, Issue 181
Contents
Research Article
- The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia
Sensory neurons perceive itch and heat-induced pain through two different receptors.
Research Resource
- Real-Time Imaging of Notch Activation with a Luciferase Complementation-Based Reporter
Luciferase complementation imaging enables quantitative analyses of Notch pathway dynamics in real time in living cells.
Perspective
- HIF Takes It Up a Notch
The interaction of the transcription factor HIF-α with the Notch receptor promotes cell fate specification and maintenance.
Editors' Choice
- Separating Obesity from Hypertension
NF-κB signaling in distinct neurons in the hypothalamus forms the link between obesity and hypertension.
- Linking Endocytosis and Tumorigenicity
Activation of receptor tyrosine kinases may not be enough for oncogenesis; excess signaling from endosomes may also be required.
- Targeting Glioma Stem Cells
Nitric oxide synthase-2 is a proliferation-promoting marker of glioma stem cells.
- Regulating ROS for Tumorigenicity
Oncogenes can activate a reactive oxygen species-detoxification program to promote tumorigenesis.
- PTEN Under Arrest
The lipid phosphatase-dependent and independent functions of PTEN are activated and inhibited, respectively, by the adaptor protein β-arrestin.
- Optineurin in Autophagic Bacterial Clearance
Phosphorylation of an autophagy receptor restricts pathogenic cytosolic bacterial growth.
