The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia

Qin Liu; Hao-Jui Weng; Kush N. Patel; Zongxiang Tang; Haihua Bai; Martin Steinhoff; Xinzhong Dong

doi:10.1126/scisignal.2001925

Research ArticleSensory Perception

The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia

Qin Liu¹,*,
Hao-Jui Weng¹,*,
Kush N. Patel¹,*,
Zongxiang Tang¹,²,
Haihua Bai¹,³,
Martin Steinhoff⁴,⁵, and
Xinzhong Dong¹,⁶,†

¹Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
²Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210046, China.
³Inner Mongolia University for the Nationalities, School of Life Science, 22 Huolinhe Street, Tongliao City 028043, China.
⁴Department of Dermatology, University of California, San Francisco, CA 94143, USA.
⁵Department of Surgery, University of California, San Francisco, CA 94143, USA.
⁶Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

↵†To whom correspondence should be addressed. E-mail: xdong2{at}jhmi.edu

↵* These authors contributed equally to this work.

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Science Signaling 12 Jul 2011:
Vol. 4, Issue 181, pp. ra45
DOI: 10.1126/scisignal.2001925

Qin Liu

1Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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Hao-Jui Weng

1Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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Kush N. Patel

1Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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Zongxiang Tang

1Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

2Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210046, China.

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Haihua Bai

1Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

3Inner Mongolia University for the Nationalities, School of Life Science, 22 Huolinhe Street, Tongliao City 028043, China.

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Martin Steinhoff

4Department of Dermatology, University of California, San Francisco, CA 94143, USA.

5Department of Surgery, University of California, San Francisco, CA 94143, USA.

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Xinzhong Dong

1Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

6Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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For correspondence: xdong2@jhmi.edu

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The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia

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