19 July 2011
Vol 4, Issue 182

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes how deacetylation of Akt and its activating kinase PDK1 promotes cell growth in physiological and pathological settings, specifically cardiac hypertrophy and cancer. The image (based on Protein Data Bank ID 1UNQ) shows the structure of the PH domain of Akt, which interacts with the lipid PIP3 (shown in space-filling form). Acetylation of Lys14 (shown in ball-and-stick form) prevents activation of Akt by PIP3. [Image: Chris Bickel, AAAS]