Contents

Contents

• Editorial Guide

  • Gatekeepers of Science and Society

    By Helena Mistry, Philip Toppin

    Science Signaling19 Jul 2011 : eg6 Full AccessRestricted Access

    Cells and society rely on information gatekeepers to identify problems and direct an appropriate response.

    • Abstract
    • Full Text
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• Research Articles

  • The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

    By Nagalingam R. Sundaresan, Vinodkumar B. Pillai, Don Wolfgeher, Sadhana Samant, Prabhakaran Vasudevan, Vishwas Parekh, Hariharasundaram Raghuraman, John M. Cunningham, Madhu Gupta, Mahesh P. Gupta

    Science Signaling19 Jul 2011 : ra46 Full AccessRestricted Access

    Deacetylation of Akt and its activating kinase PDK1 promotes cell growth in physiological and pathological settings.

    • Editor's Summary
    • Abstract
    • Full Text
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  • PreTCR and TCRγδ Signal Initiation in Thymocyte Progenitors Does Not Require Domains Implicated in Receptor Oligomerization

    By Juliet Mahtani-Patching, Joana F. Neves, Dick John Pang, Kostadin V. Stoenchev, Ana M. Aguirre-Blanco, Bruno Silva-Santos, Daniel J. Pennington

    Science Signaling19 Jul 2011 : ra47 Full AccessRestricted Access

    T cell receptor chains lacking oligomerization domains can drive the development of early thymocyte progenitors.

    • Editor's Summary
    • Abstract
    • Full Text
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• Meeting Report

  • Sequence, Structure, and Network Evolution of Protein Phosphorylation

    By Chris Soon Heng Tan

    Science Signaling19 Jul 2011 : mr6 Full AccessRestricted Access

    Analysis of phosphorylation-based signaling systems provides insight into the evolution of these regulatory molecules.

    • Abstract
    • Full Text
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• Editors' Choice

  • Finding the Right Time for a Change

    By Elizabeth M. Adler

    Science Signaling19 Jul 2011 : ec195 Full AccessRestricted Access

    The exact timing of a modulatory cholinergic signal is crucial to its effects on synaptic plasticity.

    • Abstract

  • Becoming More BAT-Like

    By Wei Wong

    Science Signaling19 Jul 2011 : ec196 Full AccessRestricted Access

    Suppression of TGF-β signaling causes white adipose tissue to adopt properties characteristic of brown adipose tissue.

    • Abstract

  • Twists and Turns in Developing Tubes

    By Annalisa M. VanHook

    Science Signaling19 Jul 2011 : ec197 Full AccessRestricted Access

    Cell shape asymmetries and oriented cell divisions shape epithelial tubes during morphogenesis.

    • Abstract

  • Orphan GPCRs, R-Spondins, and Wnt Signaling

    By Nancy R. Gough

    Science Signaling19 Jul 2011 : ec198 Full AccessRestricted Access

    R-spondins bind to the orphan GPCRs LGR4 and LGR5 to potentiate Wnt-β-catenin signaling.

    • Abstract

  • Recruiting Trouble

    By John F. Foley

    Science Signaling19 Jul 2011 : ec199 Full AccessRestricted Access

    The recruitment of a subset of monocytes to metastatic sites promotes metastasis through the release of vascular endothelial growth factor.

    • Abstract

  • c-Cbl in GPCR Resensitization and Recycling

    By Heather M. Thompson

    Science Signaling19 Jul 2011 : ec200 Full AccessRestricted Access

    Efficient recycling of an internalized G protein–coupled receptor involves the C terminus of c-Cbl.

    • Abstract

  • Introducing Bacterial Electrophysiology

    By Stella M. Hurtley

    Science Signaling19 Jul 2011 : ec201 Full AccessRestricted Access

    An optical bioprobe reveals action potential–like electrical spikes in individual bacteria.

    • Abstract

  • Crystallizing Fanconi Anemia Proteins

    By Guy Riddihough

    Science Signaling19 Jul 2011 : ec202 Full AccessRestricted Access

    The structure of the ID complex reveals how phosphorylation and ubiquitination could influence its stability and DNA-binding functions.

    • Abstract