Contents
Vol 4, Issue 182
Contents
Editorial Guide
- Gatekeepers of Science and Society
Cells and society rely on information gatekeepers to identify problems and direct an appropriate response.
Research Articles
- The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
Deacetylation of Akt and its activating kinase PDK1 promotes cell growth in physiological and pathological settings.
- PreTCR and TCRγδ Signal Initiation in Thymocyte Progenitors Does Not Require Domains Implicated in Receptor Oligomerization
T cell receptor chains lacking oligomerization domains can drive the development of early thymocyte progenitors.
Meeting Report
- Sequence, Structure, and Network Evolution of Protein Phosphorylation
Analysis of phosphorylation-based signaling systems provides insight into the evolution of these regulatory molecules.
Editors' Choice
- Finding the Right Time for a Change
The exact timing of a modulatory cholinergic signal is crucial to its effects on synaptic plasticity.
- Becoming More BAT-Like
Suppression of TGF-β signaling causes white adipose tissue to adopt properties characteristic of brown adipose tissue.
- Twists and Turns in Developing Tubes
Cell shape asymmetries and oriented cell divisions shape epithelial tubes during morphogenesis.
- Orphan GPCRs, R-Spondins, and Wnt Signaling
R-spondins bind to the orphan GPCRs LGR4 and LGR5 to potentiate Wnt-β-catenin signaling.
- Recruiting Trouble
The recruitment of a subset of monocytes to metastatic sites promotes metastasis through the release of vascular endothelial growth factor.
- c-Cbl in GPCR Resensitization and Recycling
Efficient recycling of an internalized G protein–coupled receptor involves the C terminus of c-Cbl.
- Introducing Bacterial Electrophysiology
An optical bioprobe reveals action potential–like electrical spikes in individual bacteria.
- Crystallizing Fanconi Anemia Proteins
The structure of the ID complex reveals how phosphorylation and ubiquitination could influence its stability and DNA-binding functions.
