Contents
Vol 4, Issue 183
Contents
Research Articles
- Proteome-Wide Mapping of the Drosophila Acetylome Demonstrates a High Degree of Conservation of Lysine Acetylation
Comparing the acetylomes with the phosphoproteomes of flies and humans suggests that phosphorylation sites may have evolved faster than did acetylation sites.
- A Cell-Based High-Content Screening Assay Reveals Activators and Inhibitors of Cancer Cell Invasion
Cyclin-dependent kinase 5 is identified as an anticancer target because its activity promotes invasiveness of cancer cells.
Perspective
- Stem Cell Proliferation in the Skin: α-Catenin Takes Over the Hippo Pathway
α-Catenin inhibits the transcriptional coactivator Yap to limit epidermal stem cell proliferation.
Podcast
- Science Signaling Podcast: 26 July 2011
A cell-based, high-throughput screen identifies activators and inhibitors of invadopodia formation.
Editors' Choice
- UnPINning IRAK1
Interferon production requires the activity of a prolyl isomerase on a kinase involved in Toll-like receptor signaling.
- Dendritic Cell Instructions for T Cells
An inhibitor of mitogen-activated protein kinase signaling in dendritic cells affects T cell differentiation.
- Activating β-Catenin with NCAM
An adhesion molecule may activate β-catenin signaling through a noncanonical pathway to promote cancer cell proliferation.
- Active “Par”-titioning of Bacterial Chemotaxis Proteins
Bacterial ParA-like ATPases mediate cell cycle–dependent localization of chemotaxis proteins to cell poles.
- Insight into the Sodium Channel
The crystal structure of a voltage-gated sodium channel provides insight into its voltage-dependent gating, selectivity for sodium, and blockade by drugs.
- Use It, Then Lose It
A bacterial pathogen reverses the modification of a host cell protein involved in membrane trafficking.
- Built to Invade
The structure of a eukaryotic pathogen adhesin bound to its receptor provides a basis for design of therapeutics.
- Dicty Tiger Nixes Cheaters
Polymorphic receptors prevent cheaters from avoiding altruistic cell death in Dictyostelium.
- MIEF1 as Fission Relief
MIEF1 promotes mitochondrial fusion despite recruiting the fission-promoting GTPase Drp1 to the mitochondrial membrane.
