02 August 2011
Vol 4, Issue 184

About The Cover

Cover image expansion

Online Cover This week features a Research Article that presents the structure of the light-induced dimer of VIVID, a blue-light sensor and transcriptional regulator found in the filamentous fungus Neurospora crassa. Light-induced conformational changes in one subunit of VIVID facilitate its binding to the other subunit in the dimer. The image shows the ribbon structure of the light-state dimer of VIVID against a backdrop of culture tubes containing Neurospora expressing different variants of VIVID. [Image: A. Vaidya, C.-H. Chen, J. Dunlap, J. Loros, B. Crane, Department of Chemistry and Chemical Biology, Cornell University, and Departments of Genetics and Biochemistry, Dartmouth Medical School]