16 August 2011
Vol 4, Issue 186
  • Contents

    • Research Article

    • Presentation

    • Editors' Choice

      • Acid Test

        Survival signaling downstream of a neurotrophin receptor requires a ligand that can bind stably under acidic conditions.

      • The Duality of Kif7

        Kif7 exerts both positive and negative control over hedgehog signaling through its regulation of Gli transcription factors.

      • Add Lipidation to Histone Modifications

        Calcium triggers the nuclear translocation of the acyltransferase Lpcat1, where it mediates O-palmitoylation of histone H4.

      • Stress Relief

        Stress activates p38α, which leads to enhanced surface abundance of a serotonin transporter and increased serotonin uptake.

      • Defining Boundaries with Notch

        Notch-mediated inhibition of the microRNA bantam helps to stabilize a compartment boundary by inhibiting cell proliferation and promoting actin polymerization.

About The Cover

Cover image expansion

Online Cover This week features a Research Article showing that yeast reshape the pheromone gradient through proteolysis to find partners of the opposite “sex” for mating. The image shows yeast cells expressing fluorescently tagged membrane proteins. [Image: Masur (Own work) {GFDL (, CC-BY-SA-3.0 ( or CC-BY-2.5 (}, via Wikimedia Commons]

Note: The cover image was incorrectly credited as originally published and did not include the specific license information. The credit was updated on 11 April 2013.