Contents

Contents

• Research Article

  • Yeast Dynamically Modify Their Environment to Achieve Better Mating Efficiency

    By Meng Jin, Beverly Errede, Marcelo Behar, Will Mather, Sujata Nayak, Jeff Hasty, Henrik G. Dohlman, Timothy C. Elston

    Science Signaling16 Aug 2011 : ra54 Full AccessRestricted Access

    By reshaping the pheromone gradient through proteolysis, yeast find partners of the opposite “sex” for mating.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Presentation

  • miR-221/222 Targeting of Trichorhinophalangeal 1 (TRPS1) Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer

    By Susanna Stinson, Mark R. Lackner, Alex T. Adai, Nancy Yu, Hyo-Jin Kim, Carol O’Brien, Jill Spoerke, Suchit Jhunjhunwala, Zachary Boyd, Thomas Januario, Robert J. Newman, Peng Yue, Richard Bourgon, Zora Modrusan, Howard M. Stern, Søren Warming, Frederic J. de Sauvage, Lukas Amler, Ru-Fang Yeh, David Dornan

    Science Signaling16 Aug 2011 : pt5 Full AccessRestricted Access

    MicroRNAs miR-221 and miR-222 are associated with a clinically aggressive form of breast cancer and promote epithelial-to-mesenchymal transition.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Acid Test

    By Wei Wong

    Science Signaling16 Aug 2011 : ec224 Full AccessRestricted Access

    Survival signaling downstream of a neurotrophin receptor requires a ligand that can bind stably under acidic conditions.

    • Abstract

  • The Duality of Kif7

    By Annalisa M. VanHook

    Science Signaling16 Aug 2011 : ec225 Full AccessRestricted Access

    Kif7 exerts both positive and negative control over hedgehog signaling through its regulation of Gli transcription factors.

    • Abstract

  • Add Lipidation to Histone Modifications

    By Heather M. Thompson

    Science Signaling16 Aug 2011 : ec226 Full AccessRestricted Access

    Calcium triggers the nuclear translocation of the acyltransferase Lpcat1, where it mediates O-palmitoylation of histone H4.

    • Abstract

  • Stress Relief

    By Wei Wong

    Science Signaling16 Aug 2011 : ec227 Full AccessRestricted Access

    Stress activates p38α, which leads to enhanced surface abundance of a serotonin transporter and increased serotonin uptake.

    • Abstract

  • The Right Receptor for Attention

    By Peter R. Stern

    Science Signaling16 Aug 2011 : ec228 Full AccessRestricted Access

    An important molecular mechanism involved in cognition has been unraveled.

    • Abstract

  • Defining Boundaries with Notch

    By Annalisa M. VanHook

    Science Signaling16 Aug 2011 : ec229 Full AccessRestricted Access

    Notch-mediated inhibition of the microRNA bantam helps to stabilize a compartment boundary by inhibiting cell proliferation and promoting actin polymerization.

    • Abstract