Contents
Vol 4, Issue 187
Contents
Research Article
- Tumor Progression Locus 2 Mediates Signal-Induced Increases in Cytoplasmic Calcium and Cell Migration
The kinase Tpl2 triggers calcium signaling and cell migration downstream of various receptors implicated in cancer and inflammation.
Perspective
- TBK1 Mediates Crosstalk Between the Innate Immune Response and Autophagy
Phosphorylation of an autophagy adaptor by a kinase involved in innate immune responses limits pathogenic bacterial growth.
Podcast
- Science Signaling Podcast: 23 August 2011
β2 subunit–containing nicotinic acetylcholine receptors in the prefrontal cortex are sufficient for acetylcholine-mediated enhancement of attentional focus.
Editors' Choice
- Targeting Notch to Prevent Insulin Resistance
Notch proteins drive hepatic glucose production in a FoxO1-dependent manner.
- Death by Acetylation
Reduction in acetyl-CoA and protein N-acetylation is one mechanism by which Bcl-xL exerts its antiapoptotic effect.
- Making Better Antibodies Through Inhibition
Engagement of an inhibitory receptor improves the antitumor efficacy of a monoclonal antibody.
- Florigens, Flowering, and 14-3-3 Proteins
A 14-3-3 protein bridges an interaction between rice florigen and a bZIP-containing transcription factor to activate expression of flowering genes.
- Channeling Neuronal Migration
VEGF enhances NMDAR signaling to promote granule cell migration in the developing cerebellum.
- CD36 Goes Line Dancing
Single-particle tracking suggests that some of the surface receptor CD36 is confined in elongated linear domains that promote receptor clustering and signaling.
Erratum
- A Correction to the Perspective Titled: “Intracellular Signaling and the Origins of the Sensations of Itch and Pain” by S.-K. Han and M. I. Simon
The G protein γ subunit was mislabeled in Fig. 1.
