06 September 2011
Vol 4, Issue 189
  • Contents

    • Editorial Guide

    • Research Article

    • Research Resource

    • Meeting Report

    • Podcast

    • Editors' Choice

      • Modified by Legionella

        A Legionella effector protein adds phosphocholine to Rab GTPases to manipulate membrane trafficking in host cells.

      • cAMPing in the Mitochondria

        A phosphodiesterase 2A isoform acts in concert with soluble adenylyl cyclase to create a cyclic AMP signaling domain in the mitochondrial matrix.

      • Intracellular Therapy Tool

        A synthetic biomolecular circuit identifies abnormal cell states by the integration of multiple endogenous microRNA inputs.

      • Time to Molt

        A nongrowing tracheal system limits oxygen availability to internal tissues, thereby regulating molting cycles in insects.

      • Variable Entrainment

        A positive feedback loop in a biological oscillator allows effective setting of the clock by external cues.

      • Chimeric Channels

        Engineered ion channels enable manipulation of cellular function by selective chemical control of ionic conductance.

About The Cover

Cover image expansion

Online Cover This week features an Editorial Guide that launches a month-long series on Computational and Systems Biology. The image shows a network based on the core of the epidermal growth factor to extracellular signal–regulated kinase pathway from the Research Resource by Vinayagam et al. [Image: Arunachalam Vinayagam, Max Delbrück Centrum for Molecular Medicine, Berlin]