A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction

Arunachalam Vinayagam; Ulrich Stelzl; Raphaele Foulle; Stephanie Plassmann; Martina Zenkner; Jan Timm; Heike E. Assmus; Miguel A. Andrade-Navarro; Erich E. Wanker

doi:10.1126/scisignal.2001699

Research ResourceSystems Biology

A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction

Arunachalam Vinayagam¹,*,†,
Ulrich Stelzl¹,²,*,‡,
Raphaele Foulle¹,
Stephanie Plassmann¹,
Martina Zenkner¹,
Jan Timm¹,
Heike E. Assmus³,
Miguel A. Andrade-Navarro¹, and
Erich E. Wanker¹,‡

¹AG Neuroproteomics and Computational Biology and Data Mining Group, Max Delbrück Centrum for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.
²Otto-Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, D-14195 Berlin, Germany.
³AG Systems Biology and Bioinformatics, Department of Computer Science, University of Rostock, Ulmenstrasse 69, D-18051 Rostock, Germany.

↵‡To whom correspondence should be addressed. E-mail: stelzl{at}molgen.mpg.de (U.S.); erich.w{at}mdc-berlin.de (E.E.W.)

↵* These authors contributed equally to this work.
↵† Present address: Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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Science Signaling 06 Sep 2011:
Vol. 4, Issue 189, pp. rs8
DOI: 10.1126/scisignal.2001699

Arunachalam Vinayagam

1AG Neuroproteomics and Computational Biology and Data Mining Group, Max Delbrück Centrum for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.

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Ulrich Stelzl

1AG Neuroproteomics and Computational Biology and Data Mining Group, Max Delbrück Centrum for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.

2Otto-Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, D-14195 Berlin, Germany.

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For correspondence: stelzl@molgen.mpg.de erich.w@mdc-berlin.de

Raphaele Foulle

1AG Neuroproteomics and Computational Biology and Data Mining Group, Max Delbrück Centrum for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.

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Stephanie Plassmann

1AG Neuroproteomics and Computational Biology and Data Mining Group, Max Delbrück Centrum for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.

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Martina Zenkner

1AG Neuroproteomics and Computational Biology and Data Mining Group, Max Delbrück Centrum for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.

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Jan Timm

1AG Neuroproteomics and Computational Biology and Data Mining Group, Max Delbrück Centrum for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.

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Heike E. Assmus

3AG Systems Biology and Bioinformatics, Department of Computer Science, University of Rostock, Ulmenstrasse 69, D-18051 Rostock, Germany.

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Miguel A. Andrade-Navarro

1AG Neuroproteomics and Computational Biology and Data Mining Group, Max Delbrück Centrum for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.

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Erich E. Wanker

1AG Neuroproteomics and Computational Biology and Data Mining Group, Max Delbrück Centrum for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.

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For correspondence: stelzl@molgen.mpg.de erich.w@mdc-berlin.de

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Effective prediction of the direction of signal flow in an interaction network enables modeling of signaling dynamics and identification of regulatory proteins.

A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction

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