Contents

Contents

• Research Articles

  • Protein Arginine Methyltransferase 5 Regulates ERK1/2 Signal Transduction Amplitude and Cell Fate Through CRAF

    By Pedro Andreu-Pérez, Rosaura Esteve-Puig, Carlos de Torre-Minguela, Marta López-Fauqued, Joan Josep Bech-Serra, Stephan Tenbaum, Elena R. García-Trevijano, Francesc Canals, Glenn Merlino, Matías A. Ávila, Juan A. Recio

    Science Signaling13 Sep 2011 : ra58 Full AccessRestricted Access

    Arginine methylation of RAF proteins limits ERK activation after growth factor stimulation, thereby determining the biological response.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling

    By Jamie R. Schoenborn, Ying Xim Tan, Chao Zhang, Kevan M. Shokat, Arthur Weiss

    Science Signaling13 Sep 2011 : ra59 Full AccessRestricted Access

    Signaling molecules downstream of the TCR are poised to rapidly respond to receptor activation.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspective

  • Met Receptor: A Moving Target

    By Michael J. Clague

    Science Signaling13 Sep 2011 : pe40 Full AccessRestricted Access

    Endosomal recycling pathways dictate the signaling capacity of wild-type or mutant Met receptor.

    • Abstract
    • Full Text
    • PDF

• Teaching Resources

  • Systems Biology—Biomedical Modeling

    By Eric A. Sobie, Young-Seon Lee, Sherry L. Jenkins, Ravi Iyengar

    Science Signaling13 Sep 2011 : tr2 Full AccessRestricted Access

    This course introduces students to computational principles and approaches used in systems biology.

    • Abstract
    • Full Text
    • PDF

  • Introduction to Statistical Methods to Analyze Large Data Sets: Principal Components Analysis

    By Neil R. Clark, Avi Ma’ayan

    Science Signaling13 Sep 2011 : tr3 Full AccessRestricted Access

    Lecture notes, slides, and problem sets introduce the mathematical concepts behind principal components analysis.

    • Abstract
    • Full Text
    • PDF

  • Introduction to Statistical Methods for Analyzing Large Data Sets: Gene-Set Enrichment Analysis

    By Neil R. Clark, Avi Ma’ayan

    Science Signaling13 Sep 2011 : tr4 Full AccessRestricted Access

    Lecture materials and homework assignments illustrate the mathematical concepts behind gene-set enrichment analysis (GSEA).

    • Abstract
    • Full Text
    • PDF

  • Introduction to Network Analysis in Systems Biology

    By Avi Ma’ayan

    Science Signaling13 Sep 2011 : tr5 Full AccessRestricted Access

    Lecture notes, slides, and problem sets introduce applications of graph theory and network analysis in systems biology.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 13 September 2011

    By Juan A. Recio, Annalisa M. VanHook

    Science Signaling13 Sep 2011 : pc18 Full AccessRestricted Access

    Arginine methylation of RAF determines the specificity of the biological response to growth factors that activate the same signaling cascade.

    • Abstract
    • Full Text

• Editors' Choice

  • Tug at the Heart Strings

    By L. Bryan Ray

    Science Signaling13 Sep 2011 : ec250 Full AccessRestricted Access

    Reactive oxygen species produced by NADPH oxidase link mechanical stretching to calcium signaling in mammalian myocytes.

    • Abstract

  • To Swim or Float?

    By Nancy R. Gough

    Science Signaling13 Sep 2011 : ec251 Full AccessRestricted Access

    Quorum-sensing signaling triggers a morphogenic pathway enabling bacteria to produce gas vesicles to move by adaptive flotation.

    • Abstract

  • Enhancing Basal Transmission

    By John F. Foley

    Science Signaling13 Sep 2011 : ec252 Full AccessRestricted Access

    Astrocytes respond to single axon potentials and then enhance synaptic transmission in a calcium- and purinergic signaling–dependent mechanism.

    • Abstract

  • The Repressor Within

    By Annalisa M. VanHook

    Science Signaling13 Sep 2011 : ec253 Full AccessRestricted Access

    An internal promoter drives expression of a truncated transcription factor that acts as a dominant-negative repressor of Wnt-responsive genes.

    • Abstract

  • A Wnt-Less Journey to the Nucleus?

    By Elizabeth M. Adler

    Science Signaling13 Sep 2011 : ec254 Full AccessRestricted Access

    Thalamic neurons show constitutive nuclear localization of β-catenin.

    • Abstract

  • Activated by Force

    By Wei Wong

    Science Signaling13 Sep 2011 : ec255 Full AccessRestricted Access

    An amiloride-sensitive sodium channel transduces intense mechanical stimuli in Caenorhabditis elegans.

    • Abstract

  • Reaching for Light

    By Pamela J. Hines

    Science Signaling13 Sep 2011 : ec256 Full AccessRestricted Access

    Postsynaptic plasticity participates in the adaptation of a sensory circuit to the environment.

    • Abstract

  • Unraveling Neuropathic Pain

    By Peter R. Stern

    Science Signaling13 Sep 2011 : ec257 Full AccessRestricted Access

    Action potential firing, initiated by HCN2 ion channels, is the basic mechanism underlying neuropathic pain.

    • Abstract