Contents
Vol 4, Issue 190
Contents
Research Articles
- Protein Arginine Methyltransferase 5 Regulates ERK1/2 Signal Transduction Amplitude and Cell Fate Through CRAF
Arginine methylation of RAF proteins limits ERK activation after growth factor stimulation, thereby determining the biological response.
- Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling
Signaling molecules downstream of the TCR are poised to rapidly respond to receptor activation.
Perspective
- Met Receptor: A Moving Target
Endosomal recycling pathways dictate the signaling capacity of wild-type or mutant Met receptor.
Teaching Resources
- Systems Biology—Biomedical Modeling
This course introduces students to computational principles and approaches used in systems biology.
- Introduction to Statistical Methods to Analyze Large Data Sets: Principal Components Analysis
Lecture notes, slides, and problem sets introduce the mathematical concepts behind principal components analysis.
- Introduction to Statistical Methods for Analyzing Large Data Sets: Gene-Set Enrichment Analysis
Lecture materials and homework assignments illustrate the mathematical concepts behind gene-set enrichment analysis (GSEA).
- Introduction to Network Analysis in Systems Biology
Lecture notes, slides, and problem sets introduce applications of graph theory and network analysis in systems biology.
Podcast
- Science Signaling Podcast: 13 September 2011
Arginine methylation of RAF determines the specificity of the biological response to growth factors that activate the same signaling cascade.
Editors' Choice
- Tug at the Heart Strings
Reactive oxygen species produced by NADPH oxidase link mechanical stretching to calcium signaling in mammalian myocytes.
- To Swim or Float?
Quorum-sensing signaling triggers a morphogenic pathway enabling bacteria to produce gas vesicles to move by adaptive flotation.
- Enhancing Basal Transmission
Astrocytes respond to single axon potentials and then enhance synaptic transmission in a calcium- and purinergic signaling–dependent mechanism.
- The Repressor Within
An internal promoter drives expression of a truncated transcription factor that acts as a dominant-negative repressor of Wnt-responsive genes.
- A Wnt-Less Journey to the Nucleus?
Thalamic neurons show constitutive nuclear localization of β-catenin.
- Activated by Force
An amiloride-sensitive sodium channel transduces intense mechanical stimuli in Caenorhabditis elegans.
- Reaching for Light
Postsynaptic plasticity participates in the adaptation of a sensory circuit to the environment.
- Unraveling Neuropathic Pain
Action potential firing, initiated by HCN2 ion channels, is the basic mechanism underlying neuropathic pain.