Contents
Vol 4, Issue 191
Contents
Research Articles
- A Synthetic Biology Approach Reveals a CXCR4-G13-Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells
Interfering with a specific G protein–coupled receptor pathway may provide a therapeutic approach to blocking metastasis of some forms of breast cancer.
- Shigella flexneri Infection Generates the Lipid PI5P to Alter Endocytosis and Prevent Termination of EGFR Signaling
Shigella keeps infected cells alive by preventing the lysosomal trafficking and degradation of an activated growth factor receptor.
Research Resource
- Phosphoproteomic Analysis of Salmonella-Infected Cells Identifies Key Kinase Regulators and SopB-Dependent Host Phosphorylation Events
The foodborne pathogen Salmonella triggers distinct phosphorylation events in host cells to promote infection.
Teaching Resources
- An Introduction to Dynamical Systems
Lecture notes, slides, and homework assignments illustrate a strategy for teaching.
- An Introduction to MATLAB
By practicing with simple MATLAB scripts, students learn how to interact with this commonly used platform for performing computational analyses.
- Obtaining and Estimating Kinetic Parameters from the Literature
These lecture materials describe how to create kinetic models based on information in the literature and include a student assignment.
Podcast
- Science Signaling Podcast: 20 September 2011
Activation of the small GTPase Rho downstream of a chemokine receptor is required for metastasis of some breast cancer cells.
Editors' Choice
- Stress Fractures in DNA
Prolonged adrenergic stimulation results in DNA damage through a β-arrestin1–dependent pathway.
- Shifting Signals with CXCR7
CXCR7 heterodimerizes with CXCR4, leading to preferential activation of β-arrestin–mediated signaling pathways.
- Increasing Imatinib Efficacy with Immunotherapy
Imatinib’s efficacy is mediated by directly inhibiting Kit and by indirectly relieving immunosuppression.
- Driven to Exhaustion?
The transmembrane protein Tim-3, which is associated with T cell exhaustion, enhances T cell receptor signaling pathways.
- Cell Sorting Through E-Cadherin Cleavage
Activation of metalloproteinases by EphB–ephrin-B interactions alters cell affinity by inducing localized cleavage of E-cadherin.
- Modulating Myelination
Axons signal through both glutamate and adenosine triphosphate release to regulate their insulating wraps.
- Gut Reaction
A receptor for gut hormones also functions in the brain, where its loss affects attention.
