Contents
Vol 4, Issue 192
Contents
Research Articles
- Akt Determines Cell Fate Through Inhibition of the PERK-eIF2α Phosphorylation Pathway
Inhibition of a stress-response pathway renders tumor cells more susceptible to death induced by inhibitors of phosphoinositide 3-kinase signaling.
- Time-Dependent Quantitative Multicomponent Control of the G1-S Network by the Stress-Activated Protein Kinase Hog1 upon Osmostress
The stress-activated protein kinase Hog1 delays bud morphogenesis and DNA replication through different cyclin proteins.
- Tyrosine Phosphorylation of the Gα-Interacting Protein GIV Promotes Activation of Phosphoinositide 3-Kinase During Cell Migration
GIV links ligand stimulation of various receptors to downstream activation of a kinase involved in cell migration.
Teaching Resources
- Biomedical Model Fitting and Error Analysis
Lecture notes, slides, and problem set illustrate methods for curve fitting and error analysis relevant to development of computational models for biomedical applications.
- Bistability in Biochemical Signaling Models
Lecture notes, slides, and homework assignments illustrate a strategy for teaching mathematical treatments of biological bistability.
- Computational Modeling of the Cell Cycle
Lecture notes, slides, and homework assignments based on modeling the cell cycle are used to illustrate how simulations yield biological insight.
- Developing Models in Virtual Cell
Lecture notes, slides, and a student assignment illustrate a strategy for teaching mathematical modeling using the Virtual Cell environment.
- Simulations of Stochastic Biological Phenomena
Lecture notes, slides, and a student assignment illustrate a strategy for teaching stochastic modeling of biological systems.
- Probabilistic Reasoning in Data Analysis
Lecture notes, slides, and homework assignments illustrate a strategy for teaching methods for incorporating probability in the analysis of biological data.
Editors' Choice
- First Damaging, Then Repairing
By infiltrating the epithelial layer, neutrophils cause damage but also stimulate repair.
- Calming the Storm
Activation of sphingosine 1-phosphate receptor 1 on endothelial cells suppresses the cytokine storm during influenza infection.
- Organized for Memory
The increased presence of nanoclusters of oligomeric TCRs on memory cells may enable them to mount a more rapid and vigorous response.
- Hunger Circuit
In response to food deprivation, ghrelin activates a positive feedback loop to elicit feeding behavior.
- GRK5 Goes Neuronal
GRK5 promotes neurogenesis in a kinase-independent manner by linking actin bundles to the cell membrane.
- ERK to Conserve Resources
ERK7 suppresses protein secretion in response to amino acid starvation.
