Article Information
vol. 4 no. 192 ra62
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History:
- Received October 26, 2010
- Accepted September 8, 2011
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Copyright © 2011, American Association for the Advancement of Science
Research ArticleBiochemistry
Akt Determines Cell Fate Through Inhibition of the PERK-eIF2α Phosphorylation Pathway
- Zineb Mounir1,2,*,
- Jothi Latha Krishnamoorthy1,
- Shuo Wang1,
- Barbara Papadopoulou3,
- Shirley Campbell4,
- William J. Muller4,
- Maria Hatzoglou5, and
- Antonis E. Koromilas1,6,†
- 1Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.
- 2Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1A3, Canada.
- 3Centre de Recherche en Infectiologie, Centre Hospitalier de Québec, Pavillon CHUL, Quebec, Quebec G1V 4G2, Canada.
- 4Goodman Cancer Center, McGill University, Montreal, Quebec H3G 0B1, Canada.
- 5Department of Nutrition, School of Medicine, Case Western University, Cleveland, OH 44106, USA.
- 6Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec H2W 1S6, Canada.
- ↵†To whom correspondence should be addressed. E-mail: antonis.koromilas{at}mcgill.ca
-
↵* Present address: Department of Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA.
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Sci. Signal. 27 Sep 2011:
Vol. 4, Issue 192, pp. ra62
DOI: 10.1126/scisignal.2001630
Vol. 4, Issue 192, pp. ra62
DOI: 10.1126/scisignal.2001630
Zineb Mounir
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1A3, Canada.
Jothi Latha Krishnamoorthy
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.
Shuo Wang
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.
Barbara Papadopoulou
Centre de Recherche en Infectiologie, Centre Hospitalier de Québec, Pavillon CHUL, Quebec, Quebec G1V 4G2, Canada.
Shirley Campbell
Goodman Cancer Center, McGill University, Montreal, Quebec H3G 0B1, Canada.
William J. Muller
Goodman Cancer Center, McGill University, Montreal, Quebec H3G 0B1, Canada.
Maria Hatzoglou
Department of Nutrition, School of Medicine, Case Western University, Cleveland, OH 44106, USA.
Antonis E. Koromilas
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec H2W 1S6, Canada.
