Akt Determines Cell Fate Through Inhibition of the PERK-eIF2α Phosphorylation Pathway

Zineb Mounir; Jothi Latha Krishnamoorthy; Shuo Wang; Barbara Papadopoulou; Shirley Campbell; William J. Muller; Maria Hatzoglou; Antonis E. Koromilas

doi:10.1126/scisignal.2001630

Research ArticleBiochemistry

Akt Determines Cell Fate Through Inhibition of the PERK-eIF2α Phosphorylation Pathway

Zineb Mounir¹,²,*,
Jothi Latha Krishnamoorthy¹,
Shuo Wang¹,
Barbara Papadopoulou³,
Shirley Campbell⁴,
William J. Muller⁴,
Maria Hatzoglou⁵, and
Antonis E. Koromilas¹,⁶,†

¹Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.
²Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1A3, Canada.
³Centre de Recherche en Infectiologie, Centre Hospitalier de Québec, Pavillon CHUL, Quebec, Quebec G1V 4G2, Canada.
⁴Goodman Cancer Center, McGill University, Montreal, Quebec H3G 0B1, Canada.
⁵Department of Nutrition, School of Medicine, Case Western University, Cleveland, OH 44106, USA.
⁶Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec H2W 1S6, Canada.

↵†To whom correspondence should be addressed. E-mail: antonis.koromilas{at}mcgill.ca

↵* Present address: Department of Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Science Signaling 27 Sep 2011:
Vol. 4, Issue 192, pp. ra62
DOI: 10.1126/scisignal.2001630

Zineb Mounir

1Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

2Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1A3, Canada.

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Jothi Latha Krishnamoorthy

1Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

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Shuo Wang

1Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

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Barbara Papadopoulou

3Centre de Recherche en Infectiologie, Centre Hospitalier de Québec, Pavillon CHUL, Quebec, Quebec G1V 4G2, Canada.

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Shirley Campbell

4Goodman Cancer Center, McGill University, Montreal, Quebec H3G 0B1, Canada.

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William J. Muller

4Goodman Cancer Center, McGill University, Montreal, Quebec H3G 0B1, Canada.

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Maria Hatzoglou

5Department of Nutrition, School of Medicine, Case Western University, Cleveland, OH 44106, USA.

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Antonis E. Koromilas

1Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

6Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec H2W 1S6, Canada.

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For correspondence: antonis.koromilas@mcgill.ca

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Akt Determines Cell Fate Through Inhibition of the PERK-eIF2α Phosphorylation Pathway

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