Research ArticleBiochemistry
Akt Determines Cell Fate Through Inhibition of the PERK-eIF2α Phosphorylation Pathway
- Zineb Mounir1,2,*,
- Jothi Latha Krishnamoorthy1,
- Shuo Wang1,
- Barbara Papadopoulou3,
- Shirley Campbell4,
- William J. Muller4,
- Maria Hatzoglou5, and
- Antonis E. Koromilas1,6,†
- 1Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.
- 2Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1A3, Canada.
- 3Centre de Recherche en Infectiologie, Centre Hospitalier de Québec, Pavillon CHUL, Quebec, Quebec G1V 4G2, Canada.
- 4Goodman Cancer Center, McGill University, Montreal, Quebec H3G 0B1, Canada.
- 5Department of Nutrition, School of Medicine, Case Western University, Cleveland, OH 44106, USA.
- 6Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec H2W 1S6, Canada.
- ↵†To whom correspondence should be addressed. E-mail: antonis.koromilas{at}mcgill.ca
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↵* Present address: Department of Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA.
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Sci. Signal. 27 Sep 2011:
Vol. 4, Issue 192, pp. ra62
DOI: 10.1126/scisignal.2001630
