04 October 2011
Vol 4, Issue 193
  • Contents

    • Research Articles

    • Perspective

    • Podcast

    • Editors' Choice

      • Hedgehog Travels a Painful Pathway

        Hedgehog signaling mediates nociceptive sensitization in flies and influences morphine analgesia in rats.

      • Ensuring Adequate Energy Supply

        Mitotic kinases converge at the mitochondria to promote fission and even distribution of mitochondria in dividing cells.

      • Getting Choosy

        Distinct cytoplasmic receptors detect specific pathogen-associated molecules to confer inflammasomes with ligand specificity.

      • Digital Bias

        Gender differences in finger length ratios are caused by relative differences in sex hormone signaling in developing limb buds.

      • Yin and Yang Stress Responses

        An imbalance between CRHR1-controlled anxiogenic glutamatergic and anxiolytic dopaminergic systems might lead to emotional disturbances.

      • Directing Quality Control

        A newly synthesized secretory protein quality control pathway is activated by direct binding of misfolded proteins to a sensor in the endoplasmic reticulum.

      • Calcium in Color

        Directed protein evolution provides a series of fluorescent protein–based indicators for multicolor Ca2+ imaging.

      • Go Against the Flow

        A molecular mechanism that allows lymphocytes to migrate against a chemokine gradient is revealed.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes how the kinase Itk controls the spatiotemporal patterning of T cell signaling molecules at the interface between the T cell and an antigen-presenting cell (APC) to affect the actin cytoskeleton. The image shows stills from the timed analysis of a fluorescent reporter of a T cell signaling molecule accumulating at the T cell–APC interface. [Image: Kentner Singleton, University of Texas Southwestern Medical Center, USA]