Contents
Vol 4, Issue 193
Contents
Research Articles
- Genome-Wide Analysis of a Wnt1-Regulated Transcriptional Network Implicates Neurodegenerative Pathways
A systems biology approach identifies connections between Wnt1 signaling and neurodegenerative diseases.
- Itk Controls the Spatiotemporal Organization of T Cell Activation
Loss of the kinase Itk in activated T cells disrupts actin accumulation at the immunological synapse, compromising T cell activation.
Perspective
- A WNTer Revisit: New Faces of β-Catenin and TCFs in Pluripotency
Wnt-stabilized β-catenin may enable embryonic stem cells to resist differentiation by balancing transcriptional repression and activation.
Podcast
- Science Signaling Podcast: 4 October 2011
By working together, cells can overcome the loss of information as it flows through a signaling network.
Editors' Choice
- Hedgehog Travels a Painful Pathway
Hedgehog signaling mediates nociceptive sensitization in flies and influences morphine analgesia in rats.
- Ensuring Adequate Energy Supply
Mitotic kinases converge at the mitochondria to promote fission and even distribution of mitochondria in dividing cells.
- Getting Choosy
Distinct cytoplasmic receptors detect specific pathogen-associated molecules to confer inflammasomes with ligand specificity.
- When Is a Demethylase Not a Demethylase?
The histone lysine demethylase JARID1a has demethylase-independent function in the circadian clock.
- Digital Bias
Gender differences in finger length ratios are caused by relative differences in sex hormone signaling in developing limb buds.
- Yin and Yang Stress Responses
An imbalance between CRHR1-controlled anxiogenic glutamatergic and anxiolytic dopaminergic systems might lead to emotional disturbances.
- Directing Quality Control
A newly synthesized secretory protein quality control pathway is activated by direct binding of misfolded proteins to a sensor in the endoplasmic reticulum.
- Calcium in Color
Directed protein evolution provides a series of fluorescent protein–based indicators for multicolor Ca2+ imaging.
- Not All Oxidative Stresses Are the Same
Distinct functions of Yap1 in responding to stress are dictated by the abundance of its partner Ybp1.
- Go Against the Flow
A molecular mechanism that allows lymphocytes to migrate against a chemokine gradient is revealed.
