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Abstract
New evidence has revealed interesting aspects of how the Wnt–β-catenin pathway controls self-renewal and lineage differentiation of pluripotent embryonic stem cells. Although Wnt–β-catenin signaling is dispensable for the self-renewal of naive mouse embryonic stem cells, it facilitates their expansion and resistance to differentiation through an unconventional dual mechanism involving the transcriptional repressor T cell factor (TCF) 3 and the transcriptional activator TCF1.
