Genome-Wide Analysis of a Wnt1-Regulated Transcriptional Network Implicates Neurodegenerative Pathways

Eric M. Wexler; Ezra Rosen; Daning Lu; Gregory E. Osborn; Elizabeth Martin; Helen Raybould; Daniel H. Geschwind

doi:10.1126/scisignal.2002282

Research ArticleNeuroscience

Genome-Wide Analysis of a Wnt1-Regulated Transcriptional Network Implicates Neurodegenerative Pathways

Eric M. Wexler¹,²,*,
Ezra Rosen¹,²,
Daning Lu¹,²,
Gregory E. Osborn¹,²,
Elizabeth Martin³,
Helen Raybould³, and
Daniel H. Geschwind¹,²,⁴,⁵

¹Department of Psychiatry, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.
²Program in Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.
³Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine at University of California, Davis, Davis, CA 95616, USA.
⁴Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.
⁵Department of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

↵*To whom correspondence should be addressed. E-mail: ewexler{at}ucla.edu

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Science Signaling 04 Oct 2011:
Vol. 4, Issue 193, pp. ra65
DOI: 10.1126/scisignal.2002282

Eric M. Wexler

1Department of Psychiatry, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

2Program in Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

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For correspondence: ewexler@ucla.edu

Ezra Rosen

1Department of Psychiatry, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

2Program in Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

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Daning Lu

1Department of Psychiatry, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

2Program in Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

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Gregory E. Osborn

1Department of Psychiatry, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

2Program in Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

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Elizabeth Martin

3Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine at University of California, Davis, Davis, CA 95616, USA.

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Helen Raybould

3Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine at University of California, Davis, Davis, CA 95616, USA.

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Daniel H. Geschwind

1Department of Psychiatry, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

2Program in Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

4Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

5Department of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA.

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