1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
2David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.
3Division of Immune Cell Biology, Medical Research Council, National Institute for Medical Research, London NW7 1AA, UK.
4Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA.
5Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
↵*To whom correspondence should be addressed. E-mail: christoph.wuelfing{at}UTSouthwestern.edu
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Science Signaling 04 Oct 2011: Vol. 4, Issue 193, pp. ra66 DOI: 10.1126/scisignal.2001821
Kentner L. Singleton
1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
2David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.
2David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.
Itk Controls the Spatiotemporal Organization of T Cell Activation
By Kentner L. Singleton, Monica Gosh, Radhika D. Dandekar, Byron B. Au-Yeung, Olga Ksionda, Victor L. J. Tybulewicz, Amnon Altman, Deborah J. Fowell, Christoph Wülfing
Science Signaling : ra66
Loss of the kinase Itk in activated T cells disrupts actin accumulation at the immunological synapse, compromising T cell activation.
Itk Controls the Spatiotemporal Organization of T Cell Activation
By Kentner L. Singleton, Monica Gosh, Radhika D. Dandekar, Byron B. Au-Yeung, Olga Ksionda, Victor L. J. Tybulewicz, Amnon Altman, Deborah J. Fowell, Christoph Wülfing
Science Signaling : ra66
Loss of the kinase Itk in activated T cells disrupts actin accumulation at the immunological synapse, compromising T cell activation.