Itk Controls the Spatiotemporal Organization of T Cell Activation

Kentner L. Singleton; Monica Gosh; Radhika D. Dandekar; Byron B. Au-Yeung; Olga Ksionda; Victor L. J. Tybulewicz; Amnon Altman; Deborah J. Fowell; Christoph Wülfing

doi:10.1126/scisignal.2001821

Research ArticleImmunology

Itk Controls the Spatiotemporal Organization of T Cell Activation

Kentner L. Singleton¹,
Monica Gosh¹,
Radhika D. Dandekar¹,
Byron B. Au-Yeung²,
Olga Ksionda³,
Victor L. J. Tybulewicz³,
Amnon Altman⁴,
Deborah J. Fowell², and
Christoph Wülfing¹,⁵,*

¹Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
²David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.
³Division of Immune Cell Biology, Medical Research Council, National Institute for Medical Research, London NW7 1AA, UK.
⁴Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA.
⁵Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

↵*To whom correspondence should be addressed. E-mail: christoph.wuelfing{at}UTSouthwestern.edu

See allHide authors and affiliations

Science Signaling 04 Oct 2011:
Vol. 4, Issue 193, pp. ra66
DOI: 10.1126/scisignal.2001821

Kentner L. Singleton

1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Monica Gosh

1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Radhika D. Dandekar

1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Byron B. Au-Yeung

2David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Olga Ksionda

3Division of Immune Cell Biology, Medical Research Council, National Institute for Medical Research, London NW7 1AA, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Victor L. J. Tybulewicz

3Division of Immune Cell Biology, Medical Research Council, National Institute for Medical Research, London NW7 1AA, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Amnon Altman

4Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Deborah J. Fowell

2David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christoph Wülfing

1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

5Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: christoph.wuelfing@UTSouthwestern.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Itk Controls the Spatiotemporal Organization of T Cell Activation

Plain text

Vertical Tabs

Science Signaling

Article Tools