Itk Controls the Spatiotemporal Organization of T Cell Activation

Kentner L. Singleton; Monica Gosh; Radhika D. Dandekar; Byron B. Au-Yeung; Olga Ksionda; Victor L. J. Tybulewicz; Amnon Altman; Deborah J. Fowell; Christoph Wülfing

doi:10.1126/scisignal.2001821

Research ArticleImmunology

Itk Controls the Spatiotemporal Organization of T Cell Activation

Kentner L. Singleton¹,
Monica Gosh¹,
Radhika D. Dandekar¹,
Byron B. Au-Yeung²,
Olga Ksionda³,
Victor L. J. Tybulewicz³,
Amnon Altman⁴,
Deborah J. Fowell², and
Christoph Wülfing¹,⁵,*

¹Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
²David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.
³Division of Immune Cell Biology, Medical Research Council, National Institute for Medical Research, London NW7 1AA, UK.
⁴Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA.
⁵Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

↵*To whom correspondence should be addressed. E-mail: christoph.wuelfing{at}UTSouthwestern.edu

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Science Signaling 04 Oct 2011:
Vol. 4, Issue 193, pp. ra66
DOI: 10.1126/scisignal.2001821

Kentner L. Singleton

1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Monica Gosh

1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Radhika D. Dandekar

1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Byron B. Au-Yeung

2David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.

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Olga Ksionda

3Division of Immune Cell Biology, Medical Research Council, National Institute for Medical Research, London NW7 1AA, UK.

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Victor L. J. Tybulewicz

3Division of Immune Cell Biology, Medical Research Council, National Institute for Medical Research, London NW7 1AA, UK.

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Amnon Altman

4Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA.

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Deborah J. Fowell

2David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.

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Christoph Wülfing

1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

5Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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For correspondence: christoph.wuelfing@UTSouthwestern.edu

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Itk Controls the Spatiotemporal Organization of T Cell Activation

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