11 October 2011
Vol 4, Issue 194
  • Contents

    • Research Articles

    • Perspective

    • Podcast

    • Editors' Choice

      • Fear No More

        Insulin-like growth factor 2 contributes to fear extinction.

      • A Raft to Insulin Resistance?

        Saturated fatty acids promote redistribution of c-Src into detergent-resistant membrane fractions, thereby stimulating JNK activation.

      • PKA Against P Bodies

        Attenuation of PKA activity may be required for P body formation in yeast experiencing glucose deprivation.

      • Localizing LPA Production

        Binding of the enzyme that synthesizes lysophosphatidic acid to integrins allows the production of this signaling molecule at its site of action.

      • Calming the Gut

        Interleukin-37 protects against inflammatory bowel disease in mice by inhibiting the production of proinflammatory cytokines.

      • Nerves and T Cells Connect

        Neurotransmitters relay immunosuppressive signals to T cells under pathological conditions.

About The Cover

Cover image expansion

Online Cover This week features a Research Article showing that the transcription factor Mad, which is best characterized as an effector of the bone morphogenetic protein (BMP) pathway, also participates in the Wingless pathway. The image shows a mutant fruit fly expressing a form of Mad that is resistant to BMP-induced phosphorylation in the eye. The phenotype of antenna-like tissue growing out of the eye is a developmental defect typical of excess Wingless signaling. [Image: Edward Eivers and Renee H. Choi, University of California Los Angeles, USA]