Contents
Vol 4, Issue 194
Contents
Research Articles
- Load-Induced Modulation of Signal Transduction Networks
The presence of downstream partners that interact with enzymatically modified or unmodified signaling proteins changes the dynamics of signal transduction.
- Phosphorylation of Mad Controls Competition Between Wingless and BMP Signaling
The transcription factor Mad participates in two different developmentally important signaling pathways depending on its phosphorylation status.
Perspective
- De-AMPylation Unmasked: Modulation of Host Membrane Trafficking
The reversible modification of a protein that regulates membrane trafficking promotes the replication of a bacterial pathogen.
Podcast
- Science Signaling Podcast: 11 October 2011
Phosphorylation of the transcription factor Mad determines whether it mediates Wingless or BMP signaling.
Editors' Choice
- A Raft to Insulin Resistance?
Saturated fatty acids promote redistribution of c-Src into detergent-resistant membrane fractions, thereby stimulating JNK activation.
- PKA Against P Bodies
Attenuation of PKA activity may be required for P body formation in yeast experiencing glucose deprivation.
- Localizing LPA Production
Binding of the enzyme that synthesizes lysophosphatidic acid to integrins allows the production of this signaling molecule at its site of action.
- Calming the Gut
Interleukin-37 protects against inflammatory bowel disease in mice by inhibiting the production of proinflammatory cytokines.
- Nerves and T Cells Connect
Neurotransmitters relay immunosuppressive signals to T cells under pathological conditions.