Contents

Contents

• Research Articles

  • Load-Induced Modulation of Signal Transduction Networks

    By Peng Jiang, Alejandra C. Ventura, Eduardo D. Sontag, Sofia D. Merajver, Alexander J. Ninfa, Domitilla Del Vecchio

    Science Signaling11 Oct 2011 : ra67 Full AccessRestricted Access

    The presence of downstream partners that interact with enzymatically modified or unmodified signaling proteins changes the dynamics of signal transduction.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Phosphorylation of Mad Controls Competition Between Wingless and BMP Signaling

    By Edward Eivers, Hadrien Demagny, Renee H. Choi, Edward M. De Robertis

    Science Signaling11 Oct 2011 : ra68 Full AccessRestricted Access

    The transcription factor Mad participates in two different developmentally important signaling pathways depending on its phosphorylation status.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspective

  • De-AMPylation Unmasked: Modulation of Host Membrane Trafficking

    By Hyeilin Ham, Kim Orth

    Science Signaling11 Oct 2011 : pe42 Full AccessRestricted Access

    The reversible modification of a protein that regulates membrane trafficking promotes the replication of a bacterial pathogen.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 11 October 2011

    By Edward M. De Robertis, Annalisa M. VanHook

    Science Signaling11 Oct 2011 : pc21 Full AccessRestricted Access

    Phosphorylation of the transcription factor Mad determines whether it mediates Wingless or BMP signaling.

    • Abstract
    • Full Text

• Editors' Choice

  • Fear No More

    By Nancy R. Gough

    Science Signaling11 Oct 2011 : ec282 Full AccessRestricted Access

    Insulin-like growth factor 2 contributes to fear extinction.

    • Abstract

  • A Raft to Insulin Resistance?

    By Elizabeth M. Adler

    Science Signaling11 Oct 2011 : ec283 Full AccessRestricted Access

    Saturated fatty acids promote redistribution of c-Src into detergent-resistant membrane fractions, thereby stimulating JNK activation.

    • Abstract

  • PKA Against P Bodies

    By Wei Wong

    Science Signaling11 Oct 2011 : ec284 Full AccessRestricted Access

    Attenuation of PKA activity may be required for P body formation in yeast experiencing glucose deprivation.

    • Abstract

  • Localizing LPA Production

    By Nancy R. Gough

    Science Signaling11 Oct 2011 : ec285 Full AccessRestricted Access

    Binding of the enzyme that synthesizes lysophosphatidic acid to integrins allows the production of this signaling molecule at its site of action.

    • Abstract

  • Calming the Gut

    By John F. Foley

    Science Signaling11 Oct 2011 : ec286 Full AccessRestricted Access

    Interleukin-37 protects against inflammatory bowel disease in mice by inhibiting the production of proinflammatory cytokines.

    • Abstract

  • Nerves and T Cells Connect

    By Kristen L. Mueller

    Science Signaling11 Oct 2011 : ec287 Full AccessRestricted Access

    Neurotransmitters relay immunosuppressive signals to T cells under pathological conditions.

    • Abstract