Contents
Vol 4, Issue 196
Contents
Editorial Guide
- Focus Issue: Recruiting Players for a Game of ERK
The latest research continues to add to the components and functions of the ERK mitogen-activated protein kinase signaling cascade.
Research Article
- Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size
A transcriptional coactivator in the Hippo pathway promotes cardiac growth.
Research Resources
- Proteomic and Functional Genomic Landscape of Receptor Tyrosine Kinase and Ras to Extracellular Signal–Regulated Kinase Signaling
Interactome mapping and functional genomics in Drosophila reveal common and specific components of a mitogen-activated protein kinase pathway.
- Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3
A chemical genetics strategy identified 67 previously unknown substrates of the kinase ERK2, including the transcriptional repressor ETV3.
Review
- Working Without Kinase Activity: Phosphotransfer-Independent Functions of Extracellular Signal–Regulated Kinases
ERK2 plays kinase-independent roles in chromatin remodeling, gene transcription, and cell cycle regulation.
Protocol
Podcast
- Science Signaling Podcast: 25 October 2011
A combination of functional and proteomics approaches identifies regulators of ERK signaling in Drosophila.
Editors' Choice
- Holding Back NFAT
Loss of the kinase LRRK2 promotes the activity of the transcription factor NFAT, leading to enhanced inflammatory bowel disease.
- Remembering About Cyclin E?
Cyclin E contributes to synaptic plasticity and memory independent of its role in the cell cycle.
- Bound by Oxygen
A dioxygenase binds to and inhibits a hypoxia-inducible transcription factor in the presence of oxygen.
- Allowing Apoptosis
Antagonist binding to an apoptosis inhibitor releases inhibition by promoting dimerization required for autoubiquitination.
- Electrical Synapse Plasticity
Paired bursting in coupled neurons depresses electrical synapses while their asymmetry increases after unidirectional use.
- Control and Cooperation
A beetle species synthesizes an antimicrobial peptide to constrain a bacterial symbiont in specialized organs.
- Tumor Necrosis Factor Response
Noise limits information transfer through a single signaling pathway in a single cell to just one bit.
- Poised by Noise
A stochastically activated genetic circuit enables bacteria to respond to stress.