Contents

Contents

• Editorial Guide

  • Focus Issue: Recruiting Players for a Game of ERK

    By Nancy R. Gough

    Science Signaling25 Oct 2011 : eg9 Full AccessRestricted Access

    The latest research continues to add to the components and functions of the ERK mitogen-activated protein kinase signaling cascade.

    • Abstract
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• Research Article

  • Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size

    By Mei Xin, Yuri Kim, Lillian B. Sutherland, Xiaoxia Qi, John McAnally, Robert J. Schwartz, James A. Richardson, Rhonda Bassel-Duby, Eric N. Olson

    Science Signaling25 Oct 2011 : ra70 Full AccessRestricted Access

    A transcriptional coactivator in the Hippo pathway promotes cardiac growth.

    • Editor's Summary
    • Abstract
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• Research Resources

  • Proteomic and Functional Genomic Landscape of Receptor Tyrosine Kinase and Ras to Extracellular Signal–Regulated Kinase Signaling

    By Adam A. Friedman, George Tucker, Rohit Singh, Dong Yan, Arunachalam Vinayagam, Yanhui Hu, Richard Binari, Pengyu Hong, Xiaoyun Sun, Maura Porto, Svetlana Pacifico, Thilakam Murali, Russell L. Finley Jr., John M. Asara, Bonnie Berger, Norbert Perrimon

    Science Signaling25 Oct 2011 : rs10 Full AccessRestricted Access

    Interactome mapping and functional genomics in Drosophila reveal common and specific components of a mitogen-activated protein kinase pathway.

    • Editor's Summary
    • Abstract
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  • Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3

    By Scott M. Carlson, Candace R. Chouinard, Adam Labadorf, Carol J. Lam, Katrin Schmelzle, Ernest Fraenkel, Forest M. White

    Science Signaling25 Oct 2011 : rs11 Full AccessRestricted Access

    A chemical genetics strategy identified 67 previously unknown substrates of the kinase ERK2, including the transcriptional repressor ETV3.

    • Editor's Summary
    • Abstract
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• Review

  • Working Without Kinase Activity: Phosphotransfer-Independent Functions of Extracellular Signal–Regulated Kinases

    By Javier Rodríguez, Piero Crespo

    Science Signaling25 Oct 2011 : re3 Full AccessRestricted Access

    ERK2 plays kinase-independent roles in chromatin remodeling, gene transcription, and cell cycle regulation.

    • Abstract
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• Protocol

  • ANAT: A Tool for Constructing and Analyzing Functional Protein Networks

    By Nir Yosef, Einat Zalckvar, Assaf D. Rubinstein, Max Homilius, Nir Atias, Liram Vardi, Igor Berman, Hadas Zur, Adi Kimchi, Eytan Ruppin, Roded Sharan

    Science Signaling25 Oct 2011 : pl1 Full AccessRestricted Access

    • Abstract
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• Podcast

  • Science Signaling Podcast: 25 October 2011

    By Adam A. Friedman, Norbert Perrimon, Annalisa M. VanHook

    Science Signaling25 Oct 2011 : pc22 Full AccessRestricted Access

    A combination of functional and proteomics approaches identifies regulators of ERK signaling in Drosophila.

    • Abstract
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• Editors' Choice

  • Holding Back NFAT

    By John F. Foley

    Science Signaling25 Oct 2011 : ec295 Full AccessRestricted Access

    Loss of the kinase LRRK2 promotes the activity of the transcription factor NFAT, leading to enhanced inflammatory bowel disease.

    • Abstract

  • Remembering About Cyclin E?

    By Elizabeth M. Adler

    Science Signaling25 Oct 2011 : ec296 Full AccessRestricted Access

    Cyclin E contributes to synaptic plasticity and memory independent of its role in the cell cycle.

    • Abstract

  • Bound by Oxygen

    By Wei Wong

    Science Signaling25 Oct 2011 : ec297 Full AccessRestricted Access

    A dioxygenase binds to and inhibits a hypoxia-inducible transcription factor in the presence of oxygen.

    • Abstract

  • Allowing Apoptosis

    By Valda K. Vinson

    Science Signaling25 Oct 2011 : ec298 Full AccessRestricted Access

    Antagonist binding to an apoptosis inhibitor releases inhibition by promoting dimerization required for autoubiquitination.

    • Abstract

  • Electrical Synapse Plasticity

    By Peter R. Stern

    Science Signaling25 Oct 2011 : ec299 Full AccessRestricted Access

    Paired bursting in coupled neurons depresses electrical synapses while their asymmetry increases after unidirectional use.

    • Abstract

  • Control and Cooperation

    By Caroline Ash

    Science Signaling25 Oct 2011 : ec300 Full AccessRestricted Access

    A beetle species synthesizes an antimicrobial peptide to constrain a bacterial symbiont in specialized organs.

    • Abstract

  • Tumor Necrosis Factor Response

    By L. Bryan Ray

    Science Signaling25 Oct 2011 : ec301 Full AccessRestricted Access

    Noise limits information transfer through a single signaling pathway in a single cell to just one bit.

    • Abstract

  • Poised by Noise

    By Annalisa M. VanHook

    Science Signaling25 Oct 2011 : ec302 Full AccessRestricted Access

    A stochastically activated genetic circuit enables bacteria to respond to stress.

    • Abstract