Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size

Mei Xin; Yuri Kim; Lillian B. Sutherland; Xiaoxia Qi; John McAnally; Robert J. Schwartz; James A. Richardson; Rhonda Bassel-Duby; Eric N. Olson

doi:10.1126/scisignal.2002278

Research ArticleDevelopment

Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size

Mei Xin¹,
Yuri Kim¹,
Lillian B. Sutherland¹,
Xiaoxia Qi¹,
John McAnally¹,
Robert J. Schwartz²,³,
James A. Richardson¹,⁴,
Rhonda Bassel-Duby¹, and
Eric N. Olson¹,*

¹Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390–9148, USA.
²Texas Heart Institute, Texas Medical Center, Houston, TX 77030, USA.
³Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, USA.
⁴Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390–9148, USA.

↵*To whom correspondence should be addressed. E-mail: eric.olson{at}utsouthwestern.edu

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Science Signaling 25 Oct 2011:
Vol. 4, Issue 196, pp. ra70
DOI: 10.1126/scisignal.2002278

Mei Xin

1Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390–9148, USA.

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Yuri Kim

1Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390–9148, USA.

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Lillian B. Sutherland

1Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390–9148, USA.

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Xiaoxia Qi

1Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390–9148, USA.

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John McAnally

1Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390–9148, USA.

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Robert J. Schwartz

2Texas Heart Institute, Texas Medical Center, Houston, TX 77030, USA.

3Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, USA.

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James A. Richardson

1Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390–9148, USA.

4Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390–9148, USA.

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Rhonda Bassel-Duby

1Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390–9148, USA.

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Eric N. Olson

1Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390–9148, USA.

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For correspondence: eric.olson@utsouthwestern.edu

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