Contents
Vol 4, Issue 197
Contents
Research Articles
- p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling
The tumor suppressor p53 activates miRNA-34 to inhibit Wnt signaling and colorectal cancer cell invasiveness.
- A CC′ Loop Decoy Peptide Blocks the Interaction Between Act1 and IL-17RA to Attenuate IL-17– and IL-25–Induced Inflammation
A cell-permeable peptide derived from an adaptor protein blocks cytokine receptor signaling and reduces inflammation.
- Persistent Stimulation with Interleukin-17 Desensitizes Cells Through SCFβ-TrCP-Mediated Degradation of Act1
Persistent inflammation may be prevented by degradation of an adaptor protein required for inflammatory cytokine receptor signaling.
Podcast
- Science Signaling Podcast: 1 November 2011
An engineered peptide blocks inflammation by inhibiting signaling through a proinflammatory receptor.
Editors' Choice
- Cyclic Dinucleotides Get Stung
The adaptor protein STING, which mediates the interferon response to microbial DNA, also acts as a direct sensor of cyclic dinucleotides.
- Building a Better Barrier with Broccoli?
Activation of the aryl hydrocarbon receptor in intestinal lymphocytes by dietary components contributes to intestinal immune defenses.
- Ubiquitination Activity Not Required
The ubiquitin E3 ligase activity of BRCA1 is not required for tumor suppression.
- Watching the Action
Computational and experimental results provide support for defined protein folding pathways.
- Snake Oil Revisited
A specific set of circulating fatty acids triggers cardiac hypertrophy in snakes and mammals.
- Myc Against Mycobacteria
Cytoplasmic Myc promotes antimycobacterial immune responses in macrophages.
Erratum
- A Correction to the Research Article Titled: “Time-Dependent Quantitative Multicomponent Control of the G1-S Network by the Stress-Activated Protein Kinase Hog1 upon Osmostress” by M. À. Adrover, Z. Zi, A. Duch, J. Schaber, A. González-Novo, J. Jimenez, M. Nadal-Ribelles, J. Clotet, E. Klipp, F. Posas
Errors in the labels of panels C and D of Fig. 7 and incorrect text callouts to Figs. 7E and 7F are corrected.
