Contents

Contents

• Research Articles

  • p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling

    By Nam Hee Kim, Hyun Sil Kim, Nam-Gyun Kim, Inhan Lee, Hyung-Seok Choi, Xiao-Yan Li, Shi Eun Kang, So Young Cha, Joo Kyung Ryu, Jung Min Na, Changbum Park, Kunhong Kim, Sanghyuk Lee, Barry M. Gumbiner, Jong In Yook, Stephen J. Weiss

    Science Signaling01 Nov 2011 : ra71 Full AccessRestricted Access

    The tumor suppressor p53 activates miRNA-34 to inhibit Wnt signaling and colorectal cancer cell invasiveness.

    • Editor's Summary
    • Abstract
    • Full Text
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  • A CC′ Loop Decoy Peptide Blocks the Interaction Between Act1 and IL-17RA to Attenuate IL-17– and IL-25–Induced Inflammation

    By Caini Liu, Shadi Swaidani, Wen Qian, Zizhen Kang, Paige Sun, Yue Han, Chenhui Wang, Muhammet Fatih Gulen, Weiguo Yin, Chunjiang Zhang, Paul L. Fox, Mark Aronica, Thomas A. Hamilton, Saurav Misra, Junpeng Deng, Xiaoxia Li

    Science Signaling01 Nov 2011 : ra72 Full AccessRestricted Access

    A cell-permeable peptide derived from an adaptor protein blocks cytokine receptor signaling and reduces inflammation.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Persistent Stimulation with Interleukin-17 Desensitizes Cells Through SCF^β-TrCP-Mediated Degradation of Act1

    By Peiqing Shi, Shu Zhu, Yingying Lin, Yongfeng Liu, Yan Liu, Zhijian Chen, Yufang Shi, Youcun Qian

    Science Signaling01 Nov 2011 : ra73 Full AccessRestricted Access

    Persistent inflammation may be prevented by degradation of an adaptor protein required for inflammatory cytokine receptor signaling.

    • Editor's Summary
    • Abstract
    • Full Text
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• Podcast

  • Science Signaling Podcast: 1 November 2011

    By Xiaoxia Li, Annalisa M. VanHook

    Science Signaling01 Nov 2011 : pc23 Full AccessRestricted Access

    An engineered peptide blocks inflammation by inhibiting signaling through a proinflammatory receptor.

    • Abstract
    • Full Text

• Editors' Choice

  • Cyclic Dinucleotides Get Stung

    By John F. Foley

    Science Signaling01 Nov 2011 : ec303 Full AccessRestricted Access

    The adaptor protein STING, which mediates the interferon response to microbial DNA, also acts as a direct sensor of cyclic dinucleotides.

    • Abstract

  • Building a Better Barrier with Broccoli?

    By Elizabeth M. Adler

    Science Signaling01 Nov 2011 : ec304 Full AccessRestricted Access

    Activation of the aryl hydrocarbon receptor in intestinal lymphocytes by dietary components contributes to intestinal immune defenses.

    • Abstract

  • Ubiquitination Activity Not Required

    By Annalisa M. VanHook

    Science Signaling01 Nov 2011 : ec305 Full AccessRestricted Access

    The ubiquitin E3 ligase activity of BRCA1 is not required for tumor suppression.

    • Abstract

  • Watching the Action

    By Valda K. Vinson

    Science Signaling01 Nov 2011 : ec306 Full AccessRestricted Access

    Computational and experimental results provide support for defined protein folding pathways.

    • Abstract

  • Snake Oil Revisited

    By Paula A. Kiberstis

    Science Signaling01 Nov 2011 : ec307 Full AccessRestricted Access

    A specific set of circulating fatty acids triggers cardiac hypertrophy in snakes and mammals.

    • Abstract

  • Myc Against Mycobacteria

    By Wei Wong

    Science Signaling01 Nov 2011 : ec308 Full AccessRestricted Access

    Cytoplasmic Myc promotes antimycobacterial immune responses in macrophages.

    • Abstract

• Erratum

  • A Correction to the Research Article Titled: “Time-Dependent Quantitative Multicomponent Control of the G₁-S Network by the Stress-Activated Protein Kinase Hog1 upon Osmostress” by M. À. Adrover, Z. Zi, A. Duch, J. Schaber, A. González-Novo, J. Jimenez, M. Nadal-Ribelles, J. Clotet, E. Klipp, F. Posas

    Science Signaling01 Nov 2011 : er5 Full AccessRestricted Access

    Errors in the labels of panels C and D of Fig. 7 and incorrect text callouts to Figs. 7E and 7F are corrected.

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