You are currently viewing the abstract.
View Full TextLog in to view the full text
AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.
More options
Download and print this article for your personal scholarly, research, and educational use.
Buy a single issue of Science for just $15 USD.
Abstract
This Podcast features a conversation with the senior author of a Research Article published in the 1 November 2011 issue of Science Signaling. Xiaoxia Li discusses her group’s identification of a region within the adaptor protein Act1 that is critical for its binding to the proinflammatory Interleukin-17 receptor. They designed a cell-permeable peptide that can bind to the receptor and inhibit its signaling, thus reducing inflammation, in a mouse model. Similar strategies might be successful in developing methods for blocking IL-17-dependent inflammatory disease in humans.
