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vol. 4 no. 197 ra72
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History:
- Received January 20, 2011
- Accepted October 14, 2011
- .
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Copyright © 2011, American Association for the Advancement of Science
Research ArticleImmunology
A CC′ Loop Decoy Peptide Blocks the Interaction Between Act1 and IL-17RA to Attenuate IL-17– and IL-25–Induced Inflammation
- Caini Liu1,*,
- Shadi Swaidani1,*,
- Wen Qian1,
- Zizhen Kang1,
- Paige Sun2,
- Yue Han2,
- Chenhui Wang1,
- Muhammet Fatih Gulen1,
- Weiguo Yin1,
- Chunjiang Zhang1,
- Paul L. Fox3,
- Mark Aronica4,
- Thomas A. Hamilton1,
- Saurav Misra5,
- Junpeng Deng2, and
- Xiaoxia Li1,†
- 1Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
- 2Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA.
- 3Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
- 4Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
- 5Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
- ↵†To whom correspondence should be addressed. E-mail: lix{at}ccf.org
-
↵* These authors contributed equally to this work.
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Science Signaling 01 Nov 2011:
Vol. 4, Issue 197, pp. ra72
DOI: 10.1126/scisignal.2001843
Vol. 4, Issue 197, pp. ra72
DOI: 10.1126/scisignal.2001843
Caini Liu
1Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Shadi Swaidani
1Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Wen Qian
1Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Zizhen Kang
1Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Paige Sun
2Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA.
Yue Han
2Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA.
Chenhui Wang
1Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Muhammet Fatih Gulen
1Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Weiguo Yin
1Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Chunjiang Zhang
1Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Paul L. Fox
3Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Mark Aronica
4Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Thomas A. Hamilton
1Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Saurav Misra
5Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Junpeng Deng
2Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA.
Xiaoxia Li
1Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
