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Abstract
This Podcast features a conversation with the senior author of a Report published in the 4 November 2011 issue of Science. Signaling through mTORC1 (the mammalian target of rapamycin complex 1) promotes cell growth by stimulating protein synthesis. The activity of mTORC1 is regulated by cellular nutrient and energy status as well as growth factors. The presence of amino acids stimulates the translocation of mTORC1 to the surface of the lysosome, where it is activated. Zoncu and colleagues report that the vacuolar ATPase is required for amino acids to activate mTORC1. Senior author David Sabatini discusses these findings.
