Contents
Vol 4, Issue 200
Contents
Editorial Guide
- Focus Issue: Fine-Tuning Hedgehog Signaling in Development and Disease
The Hedgehog signaling cascade is regulated by a complex and diverse set of mechanisms.
Research Articles
- Agonist-Driven Maturation and Plasma Membrane Insertion of Calcium-Sensing Receptors Dynamically Control Signal Amplitude
Activation of a G protein–coupled receptor increases its own surface abundance to enhance its signaling.
- Ric-8 Proteins Are Molecular Chaperones That Direct Nascent G Protein α Subunit Membrane Association
Control of the insertion of G protein α subunits into endomembranes by Ric-8 proteins regulates the abundance and function of heterotrimeric G proteins.
Perspective
- Barcoding Hedgehog for Intracellular Transport
Cholesterol modification may alter the intracellular localization of Hedgehog, thereby influencing where Hedgehog is released.
Presentations
- Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to Gi Proteins
Smoothened signals through small G proteins in one type of noncanonical Hedgehog signaling.
- Direct Delivery Mechanisms of Morphogen Dispersion
Cytonemes facilitate the formation of morphogen gradients by transferring signaling proteins from producing to receiving cells.
- Hedgehog Signaling and the Gli Code in Stem Cells, Cancer, and Metastases
Hedgehog signaling and the oncogenic load promote stem cell–like behavior and metastasis by influencing the balance between activator and repressor functions of Gli transcription factors.
Editors' Choice
- Coupling Oxygen to Protein Stability
In plants with sufficient oxygen, degradation by an N-end rule pathway destabilizes proteins that mediate the hypoxic gene program.
- A Scaffold for Neurodevelopment
DISC1, a susceptibility gene for neuropsychiatric disorders, interacts with various partners to influence distinct aspects of neurodevelopment.
- Ubiquitin Chain Reactions
The anti-inflammatory protein A20 inhibits NF-κB signaling through a noncatalytic mechanism by binding to polyubiquitin chains.
- Bacteria Boost Reproduction
Bacterial infection increases the fecundity of female fruit fly hosts by stimulating oocyte production.
- Arrest and Tolerate
During growth arrest, bacteria tolerate the presence of antibiotics thanks to mechanisms that protect against oxidant stress.
- Bacterial Protection
Sulfide formation helps to protect various bacteria from antibiotic toxicity.
