Gαi2 Signaling Promotes Skeletal Muscle Hypertrophy, Myoblast Differentiation, and Muscle Regeneration

Giulia C. Minetti; Jerome N. Feige; Antonia Rosenstiel; Florian Bombard; Viktor Meier; Annick Werner; Frederic Bassilana; Andreas W. Sailer; Peter Kahle; Christian Lambert; David J. Glass; Mara Fornaro

doi:10.1126/scisignal.2002038

Research ArticlePhysiology

Gα_i2 Signaling Promotes Skeletal Muscle Hypertrophy, Myoblast Differentiation, and Muscle Regeneration

Giulia C. Minetti¹,
Jerome N. Feige¹,
Antonia Rosenstiel¹,
Florian Bombard¹,
Viktor Meier¹,
Annick Werner¹,
Frederic Bassilana¹,
Andreas W. Sailer¹,
Peter Kahle¹,
Christian Lambert¹,
David J. Glass²,*, and
Mara Fornaro¹,*

¹Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.
²Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.

↵*To whom correspondence should be addressed. E-mail: mara.fornaro{at}novartis.com (M.F.); david.glass{at}novartis.com (D.J.G.)

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Science Signaling 29 Nov 2011:
Vol. 4, Issue 201, pp. ra80
DOI: 10.1126/scisignal.2002038

Giulia C. Minetti

1Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.

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Jerome N. Feige

1Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.

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Antonia Rosenstiel

1Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.

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Florian Bombard

1Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.

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Viktor Meier

1Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.

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Annick Werner

1Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.

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Frederic Bassilana

1Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.

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Andreas W. Sailer

1Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.

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Peter Kahle

1Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.

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Christian Lambert

1Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.

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David J. Glass

2Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.

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For correspondence: mara.fornaro@novartis.com david.glass@novartis.com

Mara Fornaro

1Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland.

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For correspondence: mara.fornaro@novartis.com david.glass@novartis.com

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Gα_i2 Signaling Promotes Skeletal Muscle Hypertrophy, Myoblast Differentiation, and Muscle Regeneration

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