Contents
Vol 4, Issue 202
Contents
Editorial Guide
- The Complex Art of Telling It Simply
Computational biology studies are complex; papers describing the results should not be.
Research Articles
- Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac
Whereas NGF promotes neurite outgrowth, the precursor form proNGF triggers neurite retraction.
- The SH2 Domain–Containing Proteins in 21 Species Establish the Provenance and Scope of Phosphotyrosine Signaling in Eukaryotes
Analysis of SH2 domain–containing proteins provides insights into the evolution of modular protein domains and organismal complexity.
- Protein Kinase C η Is Required for T Cell Activation and Homeostatic Proliferation
Studies of knockout mice delineate specific and overlapping roles for different protein kinase C isoforms in T cell biology.
- PDLIM2 Inhibits T Helper 17 Cell Development and Granulomatous Inflammation Through Degradation of STAT3
An E3 ubiquitin ligase inhibits the development of inflammatory T cells involved in autoimmune diseases.
Editors' Choice
- Promoting Proliferation with Nuclear Pyruvate Kinase M2
Pyruvate kinase M2 interacts with nuclear β-catenin to promote cell proliferation.
- Cancer Cell Vulnerability
The glycolytic metabolism of cancers differs from normal tissues, allowing tumor cells to survive under oxidative stress.
- Of Stress, Pain, Gender, and the Arginine Vasopressin Receptor
Variations in the vasopressin-1A receptor combine with stress level and gender to affect sensitivity to pain.
- More than a Scratch
Epidermal abrasion and T cells in the skin work together to drive the type of immune responses seen in allergy and asthma.
- Sensing H2O2 with Lyn
Peroxide oxidizes and activates the kinase Lyn to recruit neutrophils to the site of injury.
- How to Design a Better Antipsychotic?
The effectiveness of antipsychotics may be related to their effect on signaling through a GPCR heteromer.
