Protein Kinase C η Is Required for T Cell Activation and Homeostatic Proliferation

Guo Fu; Jianfang Hu; Nathalie Niederberger-Magnenat; Vasily Rybakin; Javier Casas; Pia P. Yachi; Stephanie Feldstein; Bo Ma; John A. H. Hoerter; Jeanette Ampudia; Stephanie Rigaud; Florence Lambolez; Amanda L. Gavin; Karsten Sauer; Hilde Cheroutre; Nicholas R. J. Gascoigne

doi:10.1126/scisignal.2002058

Research ArticleImmunology

Protein Kinase C η Is Required for T Cell Activation and Homeostatic Proliferation

Guo Fu¹,*,
Jianfang Hu¹,†,
Nathalie Niederberger-Magnenat¹,²,†‡,
Vasily Rybakin¹,
Javier Casas¹,
Pia P. Yachi¹,§,
Stephanie Feldstein¹,||,
Bo Ma³,§,
John A. H. Hoerter¹,
Jeanette Ampudia¹,
Stephanie Rigaud¹,
Florence Lambolez²,
Amanda L. Gavin¹,¶,
Karsten Sauer¹,
Hilde Cheroutre², and
Nicholas R. J. Gascoigne¹,*

¹Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
²Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
³Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

↵*To whom correspondence should be addressed. E-mail: gascoigne{at}scripps.edu (N.R.J.G.); guofu{at}scripps.edu (G.F.)

↵† These authors contributed equally to this work.
↵‡ Present address: Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.
↵§ Present address: Applied Molecular Evolution, 3520 Dunhill Street, San Diego, CA 92121, USA.
↵|| Present address: School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
↵¶ Present address: Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia.

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Science Signaling 06 Dec 2011:
Vol. 4, Issue 202, pp. ra84
DOI: 10.1126/scisignal.2002058

Guo Fu

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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For correspondence: gascoigne@scripps.edu guofu@scripps.edu

Jianfang Hu

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Nathalie Niederberger-Magnenat

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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Vasily Rybakin

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Javier Casas

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Pia P. Yachi

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Stephanie Feldstein

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Bo Ma

3Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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John A. H. Hoerter

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Jeanette Ampudia

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Stephanie Rigaud

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Florence Lambolez

2Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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Amanda L. Gavin

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Karsten Sauer

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Hilde Cheroutre

2Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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Nicholas R. J. Gascoigne

1Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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For correspondence: gascoigne@scripps.edu guofu@scripps.edu

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