Contents
Vol 4, Issue 203
Contents
Research Articles
- H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response
Reversible inactivation by sulfhydration of the protein tyrosine phosphatase PTP1B activates the kinase PERK to promote the ER stress response.
- Triggering Actin Comets Versus Membrane Ruffles: Distinctive Effects of Phosphoinositides on Actin Reorganization
The ability of phosphoinositides to produce functionally diverse effects may depend on the relative concentrations of different species.
Perspectives
- Is the Regulation of Insulin Signaling Multi-Organismal?
Gut microbiota in Drosophila promote metabolic signaling pathways, resulting in increased growth and development rates.
Protocols
- A Method to Separate Nuclear, Cytosolic, and Membrane-Associated Signaling Molecules in Cultured Cells
A semipermeabilization step and a specific Percoll gradient composition enable effective cellular fractionation.
Editors' Choice
- How Aldosterone Can Break Your Heart
Aldosterone promotes postinfarction cardiac rupture through the oxidation of the kinase CaMKII.
- Preventing Necrosis by Cleaving a Deubiquitinase
Cleavage of the deubiquitinase CYLD by caspase 8 prevents necrosis in response to the cytokine TNF.
- Degenerating Neurons Direct the Circuit
Larval fly neurons degenerate and produce a signal that directs the adult neurons where to migrate.
- Better Is Not Always Best
Low-affinity nutrient transporters sense depletion earlier than high-affinity transporters, thus preparing cells for starvation.
- Plant Defenses
Coordination of different defense pathways across cell compartments produces a fully effective innate immune response.
- Phosphatases Fight over fMLF
Receptor-like tyrosine phosphatases have opposing roles in regulating chemoattractant receptor signaling in mouse neutrophils.
