Contents
Vol 5, Issue 205
Contents
Editorial Guide
- 2011: Signaling Breakthroughs of the Year
Signaling breakthroughs in 2011 involved structural analyses of signaling proteins, technological advances in imaging, and insights into the mechanisms controlling gene expression, immune function, and the cellular response to stress.
Research Articles
- Inhibition of PP1 Phosphatase Activity by HBx: A Mechanism for the Activation of Hepatitis B Virus Transcription
A virus prolongs the activity of a host transcription factor to promote expression of viral genes.
- Incoherent Feedforward Control Governs Adaptation of Activated Ras in a Eukaryotic Chemotaxis Pathway
Rapid adaptation to changes in chemoattractant concentration involves an incoherent feedforward structure of the underlying signaling network.
Letters
- Comment on “Load-Induced Modulation of Signal Transduction Networks”: Reconciling Ultrasensitivity with Bifunctionality?
Mathematical modeling of a bifunctional enzyme system fails to reproduce the experimentally observed ultrasensitivity of the system.
- Response to Comment on “‘Load-Induced Modulation of Signal Transduction Networks’: Reconciling Ultrasensitivity with Bifunctionality?”
Complex biochemical and regulatory properties of a bifunctional enzyme mean that its activity cannot be modeled as a simple bifunctional system with distinct and reciprocally regulated states.
Editors' Choice
- Time to Metabolize
Components of the circadian clock repress transcription of metabolic genes by the glucocorticoid receptor.
- Myc and Metabolism
The transcription factor Myc controls the metabolic changes required for the proliferation of activated T cells.
- Shifting the Antiviral Response
Phosphorylation by IKKε of the transcription factor STAT1 tips the balance of the antiviral response from type II to type I interferon.
- Does Albumin Prime the Pump?
Albumin modulates the abundance and activity of renal Na,K-ATPase.
- Lipidation Determines Dependence
Lipid modification of Wnt ligands is required for their Wntless-mediated secretion.
- Hedgehogs Man the Gate
Hedgehog signaling is required for maintaining the integrity of the blood-brain barrier.
- Of Oncogenes and Apoptosis
Mutant K-Ras stimulates apoptosis unless countered by wild-type K-Ras.
- Mical in Actin Regulation
A protein involved in redox signaling disassembles actin filaments and alters their reassembly.
- Master Memory Modulator
A transcription factor dependent on electrical activity regulates genes involved in long-term memory formation.
