Research ArticleCell Biology

Incoherent Feedforward Control Governs Adaptation of Activated Ras in a Eukaryotic Chemotaxis Pathway

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Science Signaling  03 Jan 2012:
Vol. 5, Issue 205, pp. ra2
DOI: 10.1126/scisignal.2002413

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Adapting Incoherently

The model organism Dictyostelium moves toward higher concentrations of the chemoattractant cAMP (cyclic adenosine monophosphate), which activates a receptor that then stimulates effector proteins of the Ras family. Takeda et al. sought to understand how Dictyostelium adapts to rapid changes in chemoattractant by measuring the kinetics of Ras activation in cells exposed to cAMP. Mathematical modeling indicated that a signaling network in which the chemoattractant activates two components, which respectively activate and inhibit a third component, accurately described the data obtained from cAMP-stimulated cells. This type of network, called incoherent feedforward control, may be conserved in other chemotactic signaling networks.

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