Contents
Vol 5, Issue 207
Contents
Research Articles
- Interleukin-11 Links Oxidative Stress and Compensatory Proliferation
In dying cells, reactive oxygen species stimulate the production of a cytokine that triggers the healthy neighboring cells to proliferate.
- Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization
Semaphorin-mediated growth cone collapse may result from the GTPase-activating protein activity of dimerized plexin receptors for Rap.
Perspectives
- A Sweet Spot in the FGFR Signal Transduction Pathway
Signaling through the fibroblast growth factor receptors Heartless and Breathless requires O-GlcNAcylation of an adaptor protein.
- LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?
The kinase LRRK2 is genetically linked to diverse pathologies, including Parkinson’s and Crohn’s diseases.
Editors' Choice
- Nuclear PTEN Promotes Neuronal Survival
The Nedd4 ubiquitin ligase adaptor Ndfip1 is needed for nuclear translocation of the lipid phosphatase Pten after cerebral ischemia.
- Cocaine Controls Nuclear Import
Cocaine promotes the nuclear accumulation of histone deacetylase 5, which limits the rewarding effect of the drug.
- Long-Lasting Pain Killer
Opioid administration turns down a pain amplifier by reversing synaptic long-term potentiation in spinal nociceptive pathways.
- Adapted by Methylation
Methylation of two adaptor proteins by a bacterial effector protein prevents activation of the NF-κB pathway.
- TACE Trafficking
A pseudoprotease is required for the proteolytic cleavage of the proinflammatory cytokine tumor necrosis factor.
- Wnt Signaling and Cilia Intertwined
Wnt signaling is required for proper formation of motile cilia in zebrafish.
- Restraining Dangerous Neighbors
Exosomal secretion of microRNAs from noncancerous cells can inhibit cancer cell proliferation.
- Parasite Invasion Strategy
An evolutionarily conserved Ca2+-binding protein promotes parasite invasion.
- Fluoride Riboswitch
A fluoride-sensing riboswitch regulates the expression of putative fluoride channels in prokaryotes.
