Research ArticleBiochemistry

Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization

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Science Signaling  17 Jan 2012:
Vol. 5, Issue 207, pp. ra6
DOI: 10.1126/scisignal.2002636

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  • Response to Negishi and Buck

    We are pleased that Drs. Manabu Negishi and Matthias Buck considered our work (1) important, and did not raise any specific criticisms of our data or interpretation.

    As pointed out by Drs. Negishi and Buck, many small GTPases participate in plexin signaling. Some of them do so by direct interaction, others use indirect mechanisms. We agree that additional studies are required to reconcile some of the perplexing iss...

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    Competing Interests: None declared.
  • Ras and Rap GAP Function and GTPase Sequestration in Plexin-Mediated Cell Signaling Mechanisms

    In a recent Science Signaling paper, Zhang and colleagues report the discovery of a Rap1 GAP function for plexins. This is an important paper. However, two aspects of the report require further study.

    Ras GAP and Rap GAP function: Plexin transmembrane receptors function in diverse developmental and disease processes, including axon guidance, angiogenesis, and metastatic cell migration. The receptors are remarka...

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    Competing Interests: None declared.
  • Correction to Sequence Range

    The authors have alerted the Science Signaling Editors that the sequence range of human PlexinB1 that was amplified by polymerase chain reaction was incorrectly stated in the Materials and Methods section. The correct sequence range is 1515-2135.

    Competing Interests: None declared.

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