Contents
Vol 5, Issue 208
Contents
Research Articles
- A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria
Structure-function studies in mycobacteria reveal how a Ser-Thr protein kinase and pseudokinase work together to regulate the synthesis of the bacterial cell wall.
- Extracellular Ca2+ Acts as a Mediator of Communication from Neurons to Glia
Local decreases in extracellular calcium trigger signaling events in astrocytes that activate inhibitory neurotransmission.
Perspectives
- A Pseudokinase Debut at the Mycobacterial Cell Wall
A serine-threonine kinase targets a pseudokinase to control the synthesis of the cell wall of the bacterium that causes tuberculosis.
- Depletion of Extracellular Ca2+ Prompts Astroglia to Moderate Synaptic Network Activity
Reduced extracellular calcium stimulates astrocytes to release adenosine triphosphate, which activates inhibitory neurons and may limit excitability.
Editors' Choice
- First Sulfhydration, Then Nitrosylation
Sulfydration of a subunit of NF-κB promotes its interaction with a coactivator and stimulates production of genes encoding antiapoptotic proteins.
- Preserving a Pump with Insulin
Insulin switches pancreatic acinar cells to a primarily glycolytic metabolism under conditions of oxidative stress, allowing them to maintain ATP production.
- Tension at the Leading Edge
The increased membrane tension at the leading edge of a migrating cell maintains cell polarity.
- Taking the Myc
An RNA interference screen identifies a “druggable” enzyme whose inhibition halts tumor cell growth.
- Coordinating Synapses
The computational power of individual neurons is determined by a surprisingly precise wiring of neuronal networks.
- Stochastic or Asymmetric Fate Determination?
Cell-fate decisions in activated B lymphocytes are determined by stochastic competition.
- Natural Killer Controls
The activating receptor NKp46 is important for keeping the responses of natural killer cells in check.
