24 January 2012
Vol 5, Issue 208
  • Contents

    • Research Articles

    • Perspectives

    • Editors' Choice

      • First Sulfhydration, Then Nitrosylation

        Sulfydration of a subunit of NF-κB promotes its interaction with a coactivator and stimulates production of genes encoding antiapoptotic proteins.

      • Preserving a Pump with Insulin

        Insulin switches pancreatic acinar cells to a primarily glycolytic metabolism under conditions of oxidative stress, allowing them to maintain ATP production.

      • Tension at the Leading Edge

        The increased membrane tension at the leading edge of a migrating cell maintains cell polarity.

      • Taking the Myc

        An RNA interference screen identifies a “druggable” enzyme whose inhibition halts tumor cell growth.

      • Coordinating Synapses

        The computational power of individual neurons is determined by a surprisingly precise wiring of neuronal networks.

      • Natural Killer Controls

        The activating receptor NKp46 is important for keeping the responses of natural killer cells in check.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes how a Ser-Thr protein kinase and pseudokinase work together to regulate the synthesis of the cell wall of Mycobacterium (see also the Perspective by Warner and Mizrahi). The image is a scanning electron micrograph of Mycobacterium smegmatis, a relative of the human pathogen, Mycobacterium tuberculosis. [Image: K. Papavinasasundaram, Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA]