A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria

Christine L. Gee; Kadamba G. Papavinasasundaram; Sloane R. Blair; Christina E. Baer; Arnold M. Falick; David S. King; Jennifer E. Griffin; Harene Venghatakrishnan; Andrew Zukauskas; Jun-Rong Wei; Rakesh K. Dhiman; Dean C. Crick; Eric J. Rubin; Christopher M. Sassetti; Tom Alber

doi:10.1126/scisignal.2002525

Research ArticlesMicrobiology

A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria

Christine L. Gee¹,*,
Kadamba G. Papavinasasundaram²,*,
Sloane R. Blair¹,
Christina E. Baer¹,
Arnold M. Falick³,
David S. King³,
Jennifer E. Griffin²,
Harene Venghatakrishnan²,
Andrew Zukauskas²,
Jun-Rong Wei⁴,
Rakesh K. Dhiman⁵,
Dean C. Crick⁵,
Eric J. Rubin⁴,
Christopher M. Sassetti²,⁶,†, and
Tom Alber¹,†

¹Department of Molecular and Cell Biology, QB3 Institute, University of California, Berkeley, Berkeley, CA 94720–3220, USA.
²Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
³Howard Hughes Medical Institute Mass Spectrometry Laboratory, University of California, Berkeley, Berkeley, CA 94720–3202, USA.
⁴Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
⁵Colorado State University Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, 1682 Campus Delivery, Fort Collins, CO 80523, USA.
⁶Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01655, USA.

↵†To whom correspondence should be addressed. E-mail: christopher.sassetti{at}umassmed.edu (C.M.S.); tom{at}ucxray.berkeley.edu (T.A.)

↵* These authors contributed equally to this work.

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Science Signaling 24 Jan 2012:
Vol. 5, Issue 208, pp. ra7
DOI: 10.1126/scisignal.2002525

Christine L. Gee

1Department of Molecular and Cell Biology, QB3 Institute, University of California, Berkeley, Berkeley, CA 94720–3220, USA.

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Kadamba G. Papavinasasundaram

2Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

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Sloane R. Blair

1Department of Molecular and Cell Biology, QB3 Institute, University of California, Berkeley, Berkeley, CA 94720–3220, USA.

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Christina E. Baer

1Department of Molecular and Cell Biology, QB3 Institute, University of California, Berkeley, Berkeley, CA 94720–3220, USA.

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Arnold M. Falick

3Howard Hughes Medical Institute Mass Spectrometry Laboratory, University of California, Berkeley, Berkeley, CA 94720–3202, USA.

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David S. King

3Howard Hughes Medical Institute Mass Spectrometry Laboratory, University of California, Berkeley, Berkeley, CA 94720–3202, USA.

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Jennifer E. Griffin

2Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

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Harene Venghatakrishnan

2Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

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Andrew Zukauskas

2Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

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Jun-Rong Wei

4Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

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Rakesh K. Dhiman

5Colorado State University Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, 1682 Campus Delivery, Fort Collins, CO 80523, USA.

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Dean C. Crick

5Colorado State University Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, 1682 Campus Delivery, Fort Collins, CO 80523, USA.

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Eric J. Rubin

4Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

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Christopher M. Sassetti

2Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

6Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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For correspondence: christopher.sassetti@umassmed.edu tom@ucxray.berkeley.edu

Tom Alber

1Department of Molecular and Cell Biology, QB3 Institute, University of California, Berkeley, Berkeley, CA 94720–3220, USA.

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For correspondence: christopher.sassetti@umassmed.edu tom@ucxray.berkeley.edu

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Structure-function studies in mycobacteria reveal how a Ser-Thr protein kinase and pseudokinase work together to regulate the synthesis of the bacterial cell wall.

A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria

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