31 January 2012
Vol 5, Issue 209
  • Contents

    • Research Articles

    • Podcast

    • Editors' Choice

      • Muscling In on Fat

        Exercise triggers release of a myokine from skeletal muscle that induces the “browning” of white adipose tissue.

      • Oxygen and Two Friends

        The cerebral vasculature responds to reduced oxygen through a pathway involving carbon monoxide and hydrogen sulfide.

      • Trapped in the Plaque

        Netrin-1 enhances the retention of macrophages and the recruitment of smooth muscle cells, thereby promoting the progression of atherosclerotic lesions.

      • Protein Kinase C δ Plays Its CARD

        C-type lectin receptors activate protein kinase C δ in a Syk-dependent manner to stimulate NF-κB signaling in response to fungi.

      • Damage Switch

        ATM-mediated phosphorylation of Mdm2 after genotoxic stress causes Mdm2 to promote, rather than inhibit, p53 activity.

      • Potassium Permeation

        Structural features provide a basis for understanding gating and ion conduction of these channels.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes how a subset of myosin motor proteins binds the membrane phospholipid PIP3 to link membrane and cytoskeletal dynamics. The image shows Dictyostelium cells expressing a marker for F-actin that are undergoing chemotaxis. [Image: Chun-Lin Chen, Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD]